2ci9: Difference between revisions

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[[Image:2ci9.png|left|200px]]
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The line below this paragraph, containing "STRUCTURE_2ci9", creates the "Structure Box" on the page.
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{{STRUCTURE_2ci9|  PDB=2ci9  |  SCENE=  }}  
{{STRUCTURE_2ci9|  PDB=2ci9  |  SCENE=  }}  
===NCK1 SH2-DOMAIN IN COMPLEX WITH A DODECAPHOSPHOPEPTIDE FROM EPEC PROTEIN TIR===
===NCK1 SH2-DOMAIN IN COMPLEX WITH A DODECAPHOSPHOPEPTIDE FROM EPEC PROTEIN TIR===
{{ABSTRACT_PUBMED_16636066}}


 
==Function==
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[[http://www.uniprot.org/uniprot/NCK1_HUMAN NCK1_HUMAN]] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref> <ref>PMID:17803907</ref>
The line below this paragraph, {{ABSTRACT_PUBMED_16636066}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16636066}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:016636066</ref><references group="xtra"/>
<ref group="xtra">PMID:016636066</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Findeis, A C.]]
[[Category: Findeis, A C.]]