Sandbox Reserved 919: Difference between revisions

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===Active Site===

MGL contains an active site tunnel roughly 25Å long and 8Å wide residing beneath its lid region. Like its substrates, 2-AG and other [http://en.wikipedia.org/wiki/Monoglyceride monoacylglycerols], the tunnel is largely amphipathic. Hydrophobic residues dominate the tunnel with the exception of the terminal occluded region, which houses the [http://en.wikipedia.org/wiki/Catalytic_triad#Ser-His-Asp catalytic triad]. In its apo form, the catalytic region is not solvent-exposed, unlike the wide opening of the tunnel. <ref name="labar" /><ref name="bert" /> A unique structural motif in MGL is a 5Å solvent-exposed hole connecting the exterior to the catalytic site. This structure is proposed to act as an “exit hole” through which the glycerol product leaves MGL. The fatty acid product, namely arachidonic acid, presumably travels back through the active site tunnel. <ref name="labar" /><ref name="bert" /><ref name="shalk" />

MGL contains an active site

<scene name='57/573134/Active_tunnel/1'>tunnel</scene> roughly 25Å long and 8Å wide residing beneath its lid region. Like its substrates, 2-AG and other [http://en.wikipedia.org/wiki/Monoglyceride monoacylglycerols], the tunnel is largely amphipathic. Hydrophobic residues dominate the tunnel with the exception of the terminal occluded region, which houses the [http://en.wikipedia.org/wiki/Catalytic_triad#Ser-His-Asp catalytic triad]. In its apo form, the catalytic region is not solvent-exposed, unlike the wide opening of the tunnel. <ref name="labar" /><ref name="bert" /> A unique structural motif in MGL is a 5Å solvent-exposed hole connecting the exterior to the catalytic site. This structure is proposed to act as an “exit hole” through which the glycerol product leaves MGL. The fatty acid product, namely arachidonic acid, presumably travels back through the active site tunnel. <ref name="labar" /><ref name="bert" /><ref name="shalk" />

===Catalytic Triad===

Sandbox Reserved 919: Difference between revisions

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@@ Line 19: / Line 19: @@
 ===Active Site===
-MGL contains an active site tunnel roughly 25Å long and 8Å wide residing beneath its lid region.  Like its substrates, 2-AG and other [http://en.wikipedia.org/wiki/Monoglyceride monoacylglycerols], the tunnel is largely amphipathic. Hydrophobic residues dominate the tunnel with the exception of the terminal occluded region, which houses the [http://en.wikipedia.org/wiki/Catalytic_triad#Ser-His-Asp catalytic triad]. In its apo form, the catalytic region is not solvent-exposed, unlike the wide opening of the tunnel. <ref name="labar" /><ref name="bert" /> A unique structural motif in MGL is a 5Å solvent-exposed hole connecting the exterior to the catalytic site. This structure is proposed to act as an “exit hole” through which the glycerol product leaves MGL. The fatty acid product, namely arachidonic acid, presumably travels back through the active site tunnel. <ref name="labar" /><ref name="bert" /><ref name="shalk" />
+MGL contains an active site
+<scene name='57/573134/Active_tunnel/1'>tunnel</scene> roughly 25Å long and 8Å wide residing beneath its lid region.  Like its substrates, 2-AG and other [http://en.wikipedia.org/wiki/Monoglyceride monoacylglycerols], the tunnel is largely amphipathic. Hydrophobic residues dominate the tunnel with the exception of the terminal occluded region, which houses the [http://en.wikipedia.org/wiki/Catalytic_triad#Ser-His-Asp catalytic triad]. In its apo form, the catalytic region is not solvent-exposed, unlike the wide opening of the tunnel. <ref name="labar" /><ref name="bert" /> A unique structural motif in MGL is a 5Å solvent-exposed hole connecting the exterior to the catalytic site. This structure is proposed to act as an “exit hole” through which the glycerol product leaves MGL. The fatty acid product, namely arachidonic acid, presumably travels back through the active site tunnel. <ref name="labar" /><ref name="bert" /><ref name="shalk" />
 ===Catalytic Triad===