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| {{STRUCTURE_3s58| PDB=3s58 | SCENE= }}
| | #REDIRECT [[4oi7]] This PDB entry is obsolete and replaced by 4oi7 |
| ===RAGE recognizes nucleic acids and promotes inflammatory responses to DNA===
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| {{ABSTRACT_PUBMED_24081950}}
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| ==Function==
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| [[http://www.uniprot.org/uniprot/RAGE_HUMAN RAGE_HUMAN]] Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.<ref>PMID:19906677</ref> | |
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| ==About this Structure==
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| [[3s58]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S58 OCA].
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| ==Reference==
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| <ref group="xtra">PMID:024081950</ref><references group="xtra"/><references/>
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| [[Category: Homo sapiens]]
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| [[Category: Jin, T.]]
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| [[Category: Xiao, T.]]
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| [[Category: Extracellular]]
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| [[Category: Ig superfamily fold]]
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| [[Category: Nucleic acid binding]]
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| [[Category: Nucleic acid]]
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| [[Category: Signaling protein]]
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| [[Category: Signaling protein-dna complex]]
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| [[Category: Transport protein]]
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This PDB entry is obsolete and replaced by 4oi7
