4kel: Difference between revisions
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''' | ==Atomic resolution crystal structure of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR(N)== | ||
<StructureSection load='4kel' size='340' side='right' caption='[[4kel]], [[Resolution|resolution]] 1.15Å' scene=''> | |||
The | == Structural highlights == | ||
[[4kel]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KEL OCA]. <br> | |||
<b>Related:</b> [[2bdg|2bdg]], [[2bdi|2bdi]], [[2bdh|2bdh]], [[4k8y|4k8y]], [[4k1e|4k1e]], [[4kga|4kga]]<br> | |||
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[http://omim.org/entry/204700 204700]]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref> [[http://www.uniprot.org/uniprot/SFTI1_HELAN SFTI1_HELAN]] Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.<ref>PMID:10390350</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Buckle, A M.]] | |||
[[Category: Harris, J M.]] | |||
[[Category: Ilyichova, O V.]] | |||
[[Category: Sit, K C.]] | |||
[[Category: Swedberg, J E.]] | |||
[[Category: Veer, S J.de.]] | |||
[[Category: Bowman-birk inhibitor]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Protease]] | |||
[[Category: Protease inhibitor]] | |||
Revision as of 07:59, 30 April 2014
Atomic resolution crystal structure of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR(N)
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