2le6: Difference between revisions

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[[Image:2le6.jpg|left|200px]]
==Structure of a dimeric all-parallel-stranded G-quadruplex stacked via the 5'-to-5' interface==
<StructureSection load='2le6' size='340' side='right' caption='[[2le6]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
== Structural highlights ==
[[2le6]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LE6 OCA]. <br>
<b>Related:</b> [[1y8d|1y8d]]<br>
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
== Publication Abstract from PubMed ==
G-rich oligonucleotides T30695 (or T30923), with the sequence of (GGGT)(4), and T40214, with the sequence of (GGGC)(4), have been reported to exhibit anti-HIV and anticancer activity. Here we report on the structure of a dimeric G-quadruplex adopted by a derivative of these sequences in K(+) solution. It comprises two identical propeller-type parallel-stranded G-quadruplex subunits each containing three G-tetrad layers that are stacked via the 5'-5' interface. We demonstrated control over the stacking of the two monomeric subunits by sequence modifications. Our analysis of possible structures at the stacking interface provides a general principle for stacking of G-quadruplexes, which could have implications for the assembly and recognition of higher-order G-quadruplex structures.


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Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity.,Do NQ, Lim KW, Teo MH, Heddi B, Phan AT Nucleic Acids Res. 2011 Aug 12. PMID:21840903<ref>PMID:21840903</ref>
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{{STRUCTURE_2le6|  PDB=2le6  |  SCENE=  }}


===Structure of a dimeric all-parallel-stranded G-quadruplex stacked via the 5'-to-5' interface===
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
 
== References ==
 
<references/>
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{{ABSTRACT_PUBMED_21840903}}
 
==About this Structure==
[[2le6]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LE6 OCA].
 
==Reference==
<ref group="xtra">PMID:021840903</ref><references group="xtra"/>
[[Category: Do, N Q.]]
[[Category: Do, N Q.]]
[[Category: Heddi, B.]]
[[Category: Heddi, B.]]
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