3w69: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
[[3w69]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W69 OCA]. <br> | [[3w69]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W69 OCA]. <br> | ||
<b>[[Ligand|Ligands:]]</b> <scene name='pdbligand=LTZ:(5R,6S)-2-[((2S,5R)-2-{[(3R)-4-ACETYL-3-METHYLPIPERAZIN-1-YL]CARBONYL}-5-ETHYLPYRROLIDIN-1-YL)CARBONYL]-5,6-BIS(4-CHLOROPHENYL)-3-ISOPROPYL-6-METHYL-5,6-DIHYDROIMIDAZO[2,1-B][1,3]THIAZOLE'>LTZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br> | |||
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br> | <b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br> | ||
<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w69 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w69 RCSB], [http://www.ebi.ac.uk/pdbsum/3w69 PDBsum]</span><br> | |||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding. | [[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding. | ||
