Lac repressor: Difference between revisions
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<applet size='450' frame='true' align='right' scene='Lac_repressor/Arg51/1' /> | <applet size='450' frame='true' align='right' scene='Lac_repressor/Arg51/1' /> | ||
In the lac repressor complex with specific DNA, a pair of arginines (Arg51 in each chain) is close to the minor groove, but points away from the groove (<scene name='Lac_repressor/Arg51/1'>restore initial scene</scene>). <!--[Remove this in view of <ref>PMID: 20232938</ref>? Also this portion of the minor groove does not contain ApT or ApA (TpT) which are associated with minor groove narrowing and high negative charge density.]--> Hence the binding of arginines to narrow minor grooves does not appear to be involved in specific DNA recognition by the lac repressor. | In the lac repressor complex with specific DNA, a pair of arginines (<scene name='Lac_repressor/Arg51/1'>Arg51 in each chain</scene>) is close to the minor groove, but points away from the groove (<scene name='Lac_repressor/Arg51/1'>restore initial scene</scene>). <!--[Remove this in view of <ref>PMID: 20232938</ref>? Also this portion of the minor groove does not contain ApT or ApA (TpT) which are associated with minor groove narrowing and high negative charge density.]--> Hence the binding of arginines to narrow minor grooves does not appear to be involved in specific DNA recognition by the lac repressor. | ||
====DNA Kinks==== | ====DNA Kinks==== | ||
