4o61: Difference between revisions

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~~{{STRUCTURE_4o61| PDB=4o61 | SCENE= }}~~

==Structure of human ALKBH5 crystallized in the presence of citrate==

===Structure of human ALKBH5 crystallized in the presence of citrate===

== Structural highlights ==

==~~Function~~==

<table><tr><td colspan='2'>[[4o61]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O61 OCA].

[[http://~~www~~.~~uniprot~~.org/~~uniprot~~/~~ALKB5_HUMAN ALKB5_HUMAN~~]~~] Dioxygenase that demethylates RNA by oxidative demethylation~~: ~~specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes~~. ~~Requires molecular oxygen, alpha~~-~~ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis~~.<~~ref~~>~~PMID~~:~~21264265~~</~~ref~~> <~~ref~~>~~PMID~~:~~23177736~~</~~ref~~>

</td></tr><tr><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>

<tr><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">ALKBH5, ABH5, OFOXD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

==~~About this Structure~~==

<tr><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </td></tr>

[[~~4o61~~]] ~~is a~~ 2 ~~chain structure~~. ~~Full crystallographic information is available from~~ [http://oca.weizmann.ac.il/oca-bin/~~ocashort~~?id=~~4O61~~ OCA].

<tr><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o61 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o61 RCSB], [http://www.ebi.ac.uk/pdbsum/4o61 PDBsum]</td></tr>

<table>

==~~Reference~~==

== References ==

__TOC__

</StructureSection>

[[Category: Human]]

[[Category: Arrowsmith, C H.]]

[[Category: Bountra, C.]]

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-{{STRUCTURE_4o61|  PDB=4o61  |  SCENE=  }}
+==Structure of human ALKBH5 crystallized in the presence of citrate==
-===Structure of human ALKBH5 crystallized in the presence of citrate===
+<StructureSection load='4o61' size='340' side='right' caption='[[4o61]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+== Structural highlights ==
-==Function==
+<table><tr><td colspan='2'>[[4o61]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O61 OCA]. <br>
-[[http://www.uniprot.org/uniprot/ALKB5_HUMAN ALKB5_HUMAN]] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis.<ref>PMID:21264265</ref> <ref>PMID:23177736</ref>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene><br>
+<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALKBH5, ABH5, OFOXD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-==About this Structure==
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
-[[4o61]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O61 OCA].
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o61 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o61 RCSB], [http://www.ebi.ac.uk/pdbsum/4o61 PDBsum]</span></td></tr>
+<table>
-==Reference==
+== References ==
-<references group="xtra"/><references/>
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Human]]
 [[Category: Arrowsmith, C H.]]
 [[Category: Bountra, C.]]