2w1z: Difference between revisions
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[[ | ==ROP2 FROM TOXOPLASMA GONDII: A VIRULENCE FACTOR WITH A PROTEIN-KINASE FOLD AND NO ENZYMATIC ACTIVITY.== | ||
<StructureSection load='2w1z' size='340' side='right' caption='[[2w1z]], [[Resolution|resolution]] 1.97Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2w1z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W1Z OCA]. <br> | |||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br> | |||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w1z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w1z RCSB], [http://www.ebi.ac.uk/pdbsum/2w1z PDBsum]</span></td></tr> | |||
<table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The ROP2 protein and its paralogs are important virulence factors secreted into the host cell by the parasite Toxoplasma gondii. Here we describe the crystal structure of a large and soluble domain of mature ROP2, representative of the ROP2-like protein family. This is a structure of a protein-kinase fold that is devoid of catalytic residues and does not bind ATP. Various structural extensions constitute a signature of this protein family and act to maintain the protein kinase in an open conformation. Our ROP2 structure rules out a previous structural model of attachment of ROP2-like proteins to the parasitophorous vacuole membrane. We propose an alternative mode of membrane attachment implicating basic and amphiphatic helices present in the flexible N terminus of ROP2. | |||
ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity.,Labesse G, Gelin M, Bessin Y, Lebrun M, Papoin J, Cerdan R, Arold ST, Dubremetz JF Structure. 2009 Jan 14;17(1):139-46. PMID:19141290<ref>PMID:19141290</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
< | |||
[[Category: Toxoplasma gondii]] | [[Category: Toxoplasma gondii]] | ||
[[Category: Arold, S T.]] | [[Category: Arold, S T.]] | ||
Revision as of 08:39, 7 May 2014
ROP2 FROM TOXOPLASMA GONDII: A VIRULENCE FACTOR WITH A PROTEIN-KINASE FOLD AND NO ENZYMATIC ACTIVITY.
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