Proton Channels: Difference between revisions

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The M2 protein of influenza A virus is a proton channel. Its function is essential to infection by the virus.

The M2 protein of influenza A virus is a proton channel. Its function is essential for productive infection by the virus.

In January, 2008, crystallographic and NMR structures were published side by side for the transmembrane domains of the M2 protein: [[3bkd]] and [[2rlf]]. The former appeared to be in an open conformation blocked by amantadine, while the latter appeared to be in a closed conformation stabilized by rimantadine.

In January, 2008, crystallographic and NMR structures were published side by side in ''Nature'' for the transmembrane domains of the M2 protein: [[3bkd]] and [[2rlf]]. The former appeared to be in an open conformation blocked by amantadine, while the latter appeared to be in a closed conformation stabilized by rimantadine.

At right is a linear-interpolation morph between 3BKD and 2RLF, showing the proposed opening and closing of this channel. (Controls for animating this morph are under development.)

At right is a linear-interpolation morph between 3BKD and 2RLF, showing the proposed opening and closing of this channel.

Controls for animating this morph in the ''Scene Authoring Tools'' are under development. For now, click on "Jmol" to open the menu, and click on "Console". Enter these two commands into the bottom box of the console:

<pre>

animation mode palindrome

frame play

</pre>

To stop, then resume the animation, use these two commands one at a time:

<pre>

frame pause

frame play

</pre>

In addition to watching the animation as alpha-helical ribbons, it is useful to watch it

Proton Channels: Difference between revisions

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@@ Line 1: / Line 1: @@
-The M2 protein of influenza A virus is a proton channel. Its function is essential to infection by the virus.
+The M2 protein of influenza A virus is a proton channel. Its function is essential for productive infection by the virus.
-In January, 2008, crystallographic and NMR structures were published side by side for the transmembrane domains of the M2 protein: [[3bkd]] and [[2rlf]]. The former appeared to be in an open conformation blocked by amantadine, while the latter appeared to be in a closed conformation stabilized by rimantadine.
+In January, 2008, crystallographic and NMR structures were published side by side in ''Nature'' for the transmembrane domains of the M2 protein: [[3bkd]] and [[2rlf]]. The former appeared to be in an open conformation blocked by amantadine, while the latter appeared to be in a closed conformation stabilized by rimantadine.
 <applet load='3bkd2rlf.pdb' size='300' frame='true' align='right' caption='Linear interpolation morph from [[3bkd]] to [[2rlf| 2rlf model 1]]' />
-At right is a linear-interpolation morph between 3BKD and 2RLF, showing the proposed opening and closing of this channel. (Controls for animating this morph are under development.)
+At right is a linear-interpolation morph between 3BKD and 2RLF, showing the proposed opening and closing of this channel.
+Controls for animating this morph in the ''Scene Authoring Tools'' are under development. For now, click on "Jmol" to open the menu, and click on "Console". Enter these two commands into the bottom box of the console:
+<pre>
+animation mode palindrome
+frame play
+</pre>
+To stop, then resume the animation, use these two commands one at a time:
+<pre>
+frame pause
+frame play
+</pre>
+In addition to watching the animation as alpha-helical ribbons, it is useful to watch it