Proton Channels: Difference between revisions
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In January, 2008, crystallographic and NMR structures were published side by side in ''Nature'' for the transmembrane domains of the M2 protein: [[3bkd]] and [[2rlf]]. The former appeared to be in an open conformation blocked by amantadine, while the latter appeared to be in a closed conformation stabilized by rimantadine. | In January, 2008, crystallographic and NMR structures were published side by side in ''Nature'' for the transmembrane domains of the M2 protein: [[3bkd]] and [[2rlf]]. The former appeared to be in an open conformation blocked by amantadine, while the latter appeared to be in a closed conformation stabilized by rimantadine. | ||
<applet load='3bkd2rlf.pdb' size='400' frame='true' align='right' caption='Linear interpolation morph from [[3bkd]] to [[2rlf| 2rlf model 1]] | <applet load='3bkd2rlf.pdb' size='400' frame='true' align='right' scene='Proton_Channels/Cartoon/2' caption='Linear interpolation morph from [[3bkd]] to [[2rlf| 2rlf model 1]]' /> | ||
At right is a linear-interpolation morph between 3BKD and 2RLF, showing the proposed opening and closing of this channel. | At right is a linear-interpolation morph between 3BKD and 2RLF, showing the proposed opening and closing of this channel. | ||
In addition to watching the animation as alpha-helical ribbons, it is useful to watch it <scene name='Proton_Channels/Spacefilled/1'>spacefilled</scene>. Be sure to rotate the molecule to watch the animation from different perspectives! | In addition to watching the animation as alpha-helical ribbons, it is useful to watch it <scene name='Proton_Channels/Spacefilled/1'>spacefilled</scene>. Be sure to rotate the molecule to watch the animation from different perspectives! | ||
