Sandbox Reserved 938: Difference between revisions
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==Introduction== | |||
Mesencephalic astrocyte-derived neurotrophic factor (MANF), protein family, discovery as a protein, biological function (toxin studies, stroke, etc. - Mikko, ER-stress - Apostolou, Glembotski, etc). Receptor unknown despite broad array of function. Knock-out has been recently published, giving more broader insight into the structure-function relationship of the protein. | |||
==The structure of MANF== | |||
MANF has 2 distinc and also '''functionally''' different domains, C-terminal and N-terminal, connected by a loop. SS-bridges? | |||
===N-terminal domain=== | |||
Green link, removes C-terminal domain. Roles (Parkash, Hellman). | |||
===C-terminal domain=== | |||
Green link, removes N-terminal domain. Roles (Parkash, Hellman). | |||
==MANF in disease== | |||
