Sandbox 123: Difference between revisions
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In addition to TP domain of PBP2a, there is an allosteric domain,highlighted orange, in which the distance between <scene name='36/365380/3zfz_1/20'>the active site and the allosteric site</scene> is 60Å. | In addition to TP domain of PBP2a, there is an allosteric domain,highlighted orange, in which the distance between <scene name='36/365380/3zfz_1/20'>the active site and the allosteric site</scene> is 60Å. | ||
Allosteric site serves as a binding site for the substrate <scene name='36/365380/3zfz_1/ | Allosteric site serves as a binding site for the substrate <scene name='36/365380/3zfz_1/25'>peptidoglycan</scene>. When the substrate binds to the <scene name='36/365380/3zfz_1/21'>allosteric site</scene> (Tyr105, Asn146, Asp295, Tyr297), a conformational change occurs at the active site, opening it and allowing catalytic action to occur. | ||
The medicine, <scene name='36/365380/3zfz_1/24'>ceftaroline</scene>, mimics the substrate at the allosteric site opening the active site, allowing <scene name='36/365380/3zfz_1/22'>ceftaroline</scene> to <scene name='36/365380/3zfz_1/23'>enter and bind noncovalently</scene>. | The medicine, <scene name='36/365380/3zfz_1/24'>ceftaroline</scene>, mimics the substrate at the allosteric site opening the active site, allowing <scene name='36/365380/3zfz_1/22'>ceftaroline</scene> to <scene name='36/365380/3zfz_1/23'>enter and bind noncovalently</scene>. | ||
