Introduction to Evolutionary Conservation: Difference between revisions
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[[Image:4enl consurf150 sequence wb.jpg|400 px|left]] | [[Image:4enl consurf150 sequence wb.jpg|400 px|left]] | ||
<Structure load='' size='400' frame='true' align='right' caption='Glycolytic enzyme enolase [[4enl]] colored by evolutionary conservation.' scene='Introduction_to_Evolutionary_Conservation/Enolase_with_consurf_colors/1' /> | <Structure load='' size='400' frame='true' align='right' caption='Glycolytic enzyme enolase [[4enl]] colored by evolutionary conservation.' scene='Introduction_to_Evolutionary_Conservation/Enolase_with_consurf_colors/1' /> | ||
Notice that the conserved residues are scattered around the sequence with no obvious pattern. However, when the same colors are applied to the amino acids in the 3D structure, they form a conserved patch around the catalytic site (marked with a <span style="background:black; color:#00ff00;">''' zinc ion colored green '''</span>. | Notice that the conserved residues are scattered around the sequence with no obvious pattern. However, when the same colors are applied to the amino acids in the 3D structure (<scene name='Introduction_to_Evolutionary_Conservation/Enolase_with_consurf_colors/1'>restore initial scene</scene>), they form a conserved patch around the catalytic site (marked with a <span style="background:black; color:#00ff00;">''' zinc ion colored green '''</span>. | ||
Conserved surface patches identify functional regions of proteins. Less commonly, patches of high variability may also be functional. (Can you think of situations where high variability would be advantageous?<ref>Advantageous variability will be seen in these cases: [[5hmg]], [[2vaa]], [[3hi6]].</ref>) | Conserved surface patches identify functional regions of proteins. Less commonly, patches of high variability may also be functional. (Can you think of situations where high variability would be advantageous?<ref>Advantageous variability will be seen in these cases: [[5hmg]], [[2vaa]], [[3hi6]].</ref>) | ||
