2y7j: Difference between revisions

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~~[[Image:2y7j.png|left|200px]]~~

==STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2==

~~<!--~~

== Structural highlights ==

~~The line below this paragraph, containing "STRUCTURE_2y7j", creates the "Structure Box" on the page.~~

<table><tr><td colspan='2'>[[2y7j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7J OCA].

~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~

</td></tr><tr><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=B49:N-[2-(DIETHYLAMINO)ETHYL]-5-[(Z)-(5-FLUORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE'>B49</scene>

~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~

<tr><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </td></tr>

~~or leave the SCENE parameter empty for the default display.~~

<tr><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y7j RCSB], [http://www.ebi.ac.uk/pdbsum/2y7j PDBsum]</td></tr>

~~-->~~

<table>

~~{{STRUCTURE_2y7j| PDB=2y7j | SCENE= }}~~

== Disease ==

[[http://www.uniprot.org/uniprot/PHKG2_HUMAN PHKG2_HUMAN]] Glycogen storage disease due to liver phosphorylase kinase deficiency. The disease is caused by mutations affecting the gene represented in this entry.

===STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2===

== Function ==

[[http://www.uniprot.org/uniprot/PHKG2_HUMAN PHKG2_HUMAN]] Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity).<ref>PMID:10487978</ref>

== References ==

==~~About this Structure~~==

[[2y7j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7J OCA].

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Phosphorylase kinase]]

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@@ Line 1: / Line 1: @@
-[[Image:2y7j.png|left|200px]]
+==STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2==
+<StructureSection load='2y7j' size='340' side='right' caption='[[2y7j]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-<!--
+== Structural highlights ==
-The line below this paragraph, containing "STRUCTURE_2y7j", creates the "Structure Box" on the page.
+<table><tr><td colspan='2'>[[2y7j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7J OCA]. <br>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B49:N-[2-(DIETHYLAMINO)ETHYL]-5-[(Z)-(5-FLUORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE'>B49</scene><br>
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
-or leave the SCENE parameter empty for the default display.
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y7j RCSB], [http://www.ebi.ac.uk/pdbsum/2y7j PDBsum]</span></td></tr>
--->
+<table>
-{{STRUCTURE_2y7j|  PDB=2y7j  |  SCENE=  }}
+== Disease ==
+[[http://www.uniprot.org/uniprot/PHKG2_HUMAN PHKG2_HUMAN]] Glycogen storage disease due to liver phosphorylase kinase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
-===STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2===
+== Function ==
+[[http://www.uniprot.org/uniprot/PHKG2_HUMAN PHKG2_HUMAN]] Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity).<ref>PMID:10487978</ref>
+== References ==
-==About this Structure==
+<references/>
-[[2y7j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7J OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
 [[Category: Phosphorylase kinase]]