3a9l: Difference between revisions

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[[Image:3a9l.png|left|200px]]
==Structure of Bacteriophage poly-gamma-glutamate hydrolase==
<StructureSection load='3a9l' size='340' side='right' caption='[[3a9l]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3a9l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_phinit1 Bacillus phage phinit1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A9L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A9L FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pghP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=207656 Bacillus phage phiNIT1])</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a9l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3a9l RCSB], [http://www.ebi.ac.uk/pdbsum/3a9l PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Poly-gamma-glutamate hydrolase P (PghP) of Bacillus subtilis bacteriophage PhiNIT1 hydrolyzes the gamma-glutamyl peptide linkage of extracellular poly-gamma-glutamate produced by bacilli, which facilitates infection and propagation of phage progenies. Crystal structure of PghP was determined at a resolution of 1.9 A. Structure of PghP was elucidated as a globular protein with an open alpha/beta mixed core structure and a seven-stranded parallel/anti-parallel beta-sheet. The beta-sheet contained a core four-stranded parallel beta-sheet. A zinc-binding motif, His-Glu-His, was identified at the C-terminal end of the beta-sheet. Structure analysis demonstrated that PghP, which had not been previously classified into any peptidase/protease family due to lack of amino acid sequence similarity with known enzymes, had a catalytic center containing a zinc ion and an overall topology resembling mammalian carboxypeptidase A and related enzymes. Structural comparisons indicated important amino acid residues of PghP for catalysis and recognition of the gamma-peptide bond of poly-gamma-glutamate, which was confirmed by site-directed mutagenesis of PghP. Proteins 2011. (c) 2012 Wiley Periodicals, Inc.


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Crystal structure of bacteriophage varphiNIT1 zinc peptidase PghP that hydrolyzes gamma-glutamyl linkage of bacterial poly-gamma-glutamate.,Fujimoto Z, Kimura K Proteins. 2012 Mar;80(3):722-32. doi: 10.1002/prot.23229. Epub 2011 Nov 22. PMID:22105902<ref>PMID:22105902</ref>
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{{STRUCTURE_3a9l|  PDB=3a9l  |  SCENE=  }}


===Structure of Bacteriophage poly-gamma-glutamate hydrolase===
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
 
</div>
 
== References ==
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{{ABSTRACT_PUBMED_22105902}}
 
==About this Structure==
[[3a9l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_phinit1 Bacillus phage phinit1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A9L OCA].
 
==Reference==
<ref group="xtra">PMID:022105902</ref><ref group="xtra">PMID:019724131</ref><ref group="xtra">PMID:012732513</ref><references group="xtra"/>
[[Category: Bacillus phage phinit1]]
[[Category: Bacillus phage phinit1]]
[[Category: Fujimoto, Z.]]
[[Category: Fujimoto, Z.]]
Retrieved from "https://proteopedia.org/3a9l"