Sandbox Reserved 930: Difference between revisions
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==Introduction== | ==Introduction== | ||
[[Image:Actin myosin anim.gif| | [[Image:Actin myosin anim.gif|400px|left|thumb| Figure 1. The movement of myosin motor domain on actin filament]] | ||
[[Image:myosin.png| | [[Image:myosin.png|450px|right|thumb| Figure 2. The contractile cycle of the myosin head]] | ||
In the striated muscle the actin and myosin proteins form ordered basic units called sarcomeres. Muscle contraction is achieved by the mechanical sliding of myosin filament (thick filament) along the actin filament (thin filament), Fig. 1. The major constituent of the myosin filament is myosin, a motor protein responsible for converting chemical energy to mechanical movement. In the presence of Ca<sup>2+</sup> and Mg<sup>2+</sup>, myosin is able to cyclically bind ATP and hydrolyse it to ADP + P<sub>i</sub> , triggering subsequent myosin-actin detachment, reattachment and power stroke, so called contractile reaction (Fig.2). | In the striated muscle the actin and myosin proteins form ordered basic units called sarcomeres. Muscle contraction is achieved by the mechanical sliding of myosin filament (thick filament) along the actin filament (thin filament), Fig. 1. The major constituent of the myosin filament is myosin, a motor protein responsible for converting chemical energy to mechanical movement. In the presence of Ca<sup>2+</sup> and Mg<sup>2+</sup>, myosin is able to cyclically bind ATP and hydrolyse it to ADP + P<sub>i</sub> , triggering subsequent myosin-actin detachment, reattachment and power stroke, so called contractile reaction (Fig.2). | ||
