Sandbox Reserved 932: Difference between revisions

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There are no significant differences in the sequence of functionally important loops A-F of nAChR in mice and chicks. However in the prior region of loop F, chicks have several changes in their amino acid composition leading to introduction of positive charge in the front of the functionally active loop F. This might have important functionality in the attraction and binding of denmotoxin specifically to bird nAChRs.  
There are no significant differences in the sequence of functionally important loops A-F of nAChR in mice and chicks. However in the prior region of loop F, chicks have several changes in their amino acid composition leading to introduction of positive charge in the front of the functionally active loop F. This might have important functionality in the attraction and binding of denmotoxin specifically to bird nAChRs.  


Snakes and some other terrestrial animals such as mongoose have achieved resistance to denmotoxin by introducing a mutation to asparagine (e.g. W→N) in one of the aromatic AChR binding residues (see fig.). This allows introduction of N-glycolysation inside the binding pocket leading to spatial inhibition of denmotoxin binding, but still allowing the natural ligand ACh to interact with the receptor. 


===Conclusions===
===Conclusions===
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