Sandbox Reserved 932: Difference between revisions
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===Conclusions=== | ===Conclusions=== | ||
3FTXs are the most abundant and well characterized snake venom protein family. Whilst the highly conserved three finger structural motif is present in denmotoxin | 3FTXs are the most abundant and well characterized snake venom protein family. The broad spectrum of 3FTX targets, including nAChRs, phospholipids and L-type calcium channels, make the proteins interesting for research. The interaction of the 3FTX with their targets result in a myriad of pharmacological effects. Understanding how the architecture of the proteins of the family result in the varying mechanism actions can prove a valuable tool for rational drug desing. | ||
Whilst the highly conserved three finger structural motif is present in denmotoxin minor structural differences can be found when compared to other proteins of family. These differences are responsible for the recognition of target receptors and can modulate both the specificity and toxicity of the venom. | |||
</StructureSection> | </StructureSection> | ||
