Sandbox Reserved 932: Difference between revisions
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=== Interaction with nicotinic acetylcholine receptor === | === Interaction model with nicotinic acetylcholine receptor === | ||
[[Image:Bungarotoxin interaction with nACHr figure text.png|300px|right|thumb| Suggested interaction of α-bungarotoxin in binding pocket of nAChR (simplified figure) [PDB=4HQP]]] | [[Image:Bungarotoxin interaction with nACHr figure text.png|300px|right|thumb| Suggested interaction of '''α-bungarotoxin''' in binding pocket of nAChR (simplified figure) [PDB=4HQP]]] | ||
Most of the 3FTX family proteins possess a highly conserved arginine in the tip of their binding loop responsible for interaction with nAChRs. This interaction was determined by resolving a structure of α7 nAChR chimera in a complex with α-bungarotoxin (see fig.). In denmotoxin, this loop contains several changes in its sequence; arginine has replaced by aspartic acid (ASP41) and two additional glutamates (GLU42 & GLU45) generate untypical <scene name='57/579702/Negative_charge/1'>negative charge</scene> into the loop. | Most of the 3FTX family proteins possess a highly conserved arginine in the tip of their binding loop responsible for interaction with nAChRs. This interaction was determined by resolving a structure of α7 nAChR chimera in a complex with α-bungarotoxin (see fig.). In denmotoxin, this loop contains several changes in its sequence; arginine has replaced by aspartic acid (ASP41) and two additional glutamates (GLU42 & GLU45) generate untypical <scene name='57/579702/Negative_charge/1'>negative charge</scene> into the loop. | ||
