Sandbox Reserved 932: Difference between revisions

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One of the most well characterized snake venom protein families is the Three-finger-toxins (3FTX). These proteins consist of three β-stranded finger-like polypeptide loops stabilized by four disulphide bridges on the surface of a globular core. In non-convential 3TFXs a fifth disulphide bridge can be present as is the case in Denmotoxin. The crystal structure of denmotoxin was solved to 1.9Å by molecular replacement method.
One of the most well characterized snake venom protein families is the Three-finger-toxins (3FTX). These proteins consist of three β-stranded finger-like polypeptide loops stabilized by four disulphide bridges on the surface of a globular core. In non-convential 3TFXs a fifth disulphide bridge can be present as is the case in Denmotoxin. The crystal structure of denmotoxin was solved to 1.9Å by molecular replacement method.


Denmotoxin binds specifically to bird muscle nicotinic acetylcholine receptors preventing their normal function in signal transduction. This taxon specifity is reached by unique structural differences to other 3FTXs such as changes in the suggested binding loop of the protein. <ref>Pawlak J. , [article_link "article_name"], ''publisher'', publication_date. Retrieved retrieved_date.</ref><ref>{{cite news
Denmotoxin binds specifically to bird muscle nicotinic acetylcholine receptors preventing their normal function in signal transduction. This taxon specifity is reached by unique structural differences to other 3FTXs such as changes in the suggested binding loop of the protein. <ref>Pawlak J. ''et al.'', [http://www.ncbi.nlm.nih.gov/pubmed/16864572 "Denmotoxin, a Three-finger Toxin from the Colubrid Snake Boiga dendrophila (Mangrove Catsnake) with Bird-specific Activity"], ''The Journal of Biological Chemistry: 281: 29030-29041'', September 29, 2006. Retrieved May 19, 2014.</ref>
| author = Pawlak J. ''et al.''
| title = Denmotoxin, a Three-finger Toxin from the Colubrid Snake Boiga dendrophila (Mangrove Catsnake) with Bird-specific Activity
| quote =
| newspaper = The Journal of Biological Chemistry: 281: 29030-29041
| date = September 29, 2006
| pages =
| url =
| accessdate =
}}</ref>
 
=Denmotoxin=
=Denmotoxin=
<StructureSection load='2H5F' size='450' side='right'  
<StructureSection load='2H5F' size='450' side='right'  
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