1a4g: Difference between revisions

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[[Image:1a4g.gif|left|200px]]<br /><applet load="1a4g" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1a4g.gif|left|200px]]
caption="1a4g, resolution 2.2&Aring;" />
 
'''INFLUENZA VIRUS B/BEIJING/1/87 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR'''<br />
{{Structure
|PDB= 1a4g |SIZE=350|CAPTION= <scene name='initialview01'>1a4g</scene>, resolution 2.2&Aring;
|SITE= <scene name='pdbsite=CHA:High+Affinity+Ca+Binding+Site+In+Chain+A'>CHA</scene>, <scene name='pdbsite=CHB:High+Affinity+Ca+Binding+Site+In+Chain+B'>CHB</scene>, <scene name='pdbsite=CLA:Low+Affinity+Ca+Binding+Site+In+Chain+A'>CLA</scene>, <scene name='pdbsite=CLB:N/Low+Affinity+Ca+Binding+Site+In+Chain+B'>CLB</scene>, <scene name='pdbsite=ZAA:Binding+Site+For+Zanamivir+In+Chain+A'>ZAA</scene> and <scene name='pdbsite=ZAB:Binding+Site+For+Zanamivir+In+Chain+B'>ZAB</scene>
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=ZMR:ZANAMIVIR'>ZMR</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18]
|GENE=
}}
 
'''INFLUENZA VIRUS B/BEIJING/1/87 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1A4G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=ZMR:'>ZMR</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] Known structural/functional Sites: <scene name='pdbsite=CHA:High+Affinity+Ca+Binding+Site+In+Chain+A'>CHA</scene>, <scene name='pdbsite=CHB:High+Affinity+Ca+Binding+Site+In+Chain+B'>CHB</scene>, <scene name='pdbsite=CLA:Low+Affinity+Ca+Binding+Site+In+Chain+A'>CLA</scene>, <scene name='pdbsite=CLB:N/Low+Affinity+Ca+Binding+Site+In+Chain+B'>CLB</scene>, <scene name='pdbsite=ZAA:Binding+Site+For+Zanamivir+In+Chain+A'>ZAA</scene> and <scene name='pdbsite=ZAB:Binding+Site+For+Zanamivir+In+Chain+B'>ZAB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4G OCA].  
1A4G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A4G OCA].  


==Reference==
==Reference==
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B., Taylor NR, Cleasby A, Singh O, Skarzynski T, Wonacott AJ, Smith PW, Sollis SL, Howes PD, Cherry PC, Bethell R, Colman P, Varghese J, J Med Chem. 1998 Mar 12;41(6):798-807. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9526556 9526556]
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B., Taylor NR, Cleasby A, Singh O, Skarzynski T, Wonacott AJ, Smith PW, Sollis SL, Howes PD, Cherry PC, Bethell R, Colman P, Varghese J, J Med Chem. 1998 Mar 12;41(6):798-807. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9526556 9526556]
[[Category: Exo-alpha-sialidase]]
[[Category: Exo-alpha-sialidase]]
[[Category: Influenza b virus]]
[[Category: Influenza b virus]]
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[[Category: hydrolase]]
[[Category: hydrolase]]


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