4jm0: Difference between revisions

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~~{{STRUCTURE_4jm0| PDB=4jm0 | SCENE= }}~~

==Structure of Human Cytomegalovirus Immune Modulator UL141==

===Structure of Human Cytomegalovirus Immune Modulator UL141===

== Structural highlights ==

==~~Function~~==

<table><tr><td colspan='2'>[[4jm0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hcmvm Hcmvm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JM0 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JM0 FirstGlance].

[[~~http://www.uniprot.org/uniprot/UL141_HCMVM UL141_HCMVM~~]] ~~Evasion of NK cell killing~~. Blocks surface expression of PVR which is a ligand for NK cell-activating receptors. Binds human PVR in the endoplasmic reticulum and prevents its maturation and transport to the cell surface. Targets also the natural killer cell activating ligand PVRL2/Nectin-2 for proteasome-mediated degradation.<ref>~~PMID:20410314</ref>~~

</td></tr><tr><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>

<tr><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4i9x|4i9x]]</td></tr>

==~~About this Structure~~==

<tr><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jm0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jm0 RCSB], [http://www.ebi.ac.uk/pdbsum/4jm0 PDBsum]</td></tr>

[[4jm0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JM0 OCA].

<table>

__TOC__

==~~Reference~~==

</StructureSection>

<~~references group~~="~~xtra~~"/><~~references~~/>

[[Category: Hcmvm]]

[[Category: Nemcovicova, I.]]

[[Category: Zajonc, D M.]]

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-{{STRUCTURE_4jm0|  PDB=4jm0  |  SCENE=  }}
+==Structure of Human Cytomegalovirus Immune Modulator UL141==
-===Structure of Human Cytomegalovirus Immune Modulator UL141===
+<StructureSection load='4jm0' size='340' side='right' caption='[[4jm0]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
+== Structural highlights ==
-==Function==
+<table><tr><td colspan='2'>[[4jm0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hcmvm Hcmvm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JM0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JM0 FirstGlance]. <br>
-[[http://www.uniprot.org/uniprot/UL141_HCMVM UL141_HCMVM]] Evasion of NK cell killing. Blocks surface expression of PVR which is a ligand for NK cell-activating receptors. Binds human PVR in the endoplasmic reticulum and prevents its maturation and transport to the cell surface. Targets also the natural killer cell activating ligand PVRL2/Nectin-2 for proteasome-mediated degradation.<ref>PMID:20410314</ref>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4i9x|4i9x]]</td></tr>
-==About this Structure==
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jm0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jm0 RCSB], [http://www.ebi.ac.uk/pdbsum/4jm0 PDBsum]</span></td></tr>
-[[4jm0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JM0 OCA].
+<table>
+__TOC__
-==Reference==
+</StructureSection>
-<references group="xtra"/><references/>
+[[Category: Hcmvm]]
 [[Category: Nemcovicova, I.]]
 [[Category: Zajonc, D M.]]