1a5s: Difference between revisions

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[[Image:1a5s.gif|left|200px]]<br /><applet load="1a5s" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1a5s.gif|left|200px]]
caption="1a5s, resolution 2.30&Aring;" />
 
'''CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUOROINDOLE PROPANOL PHOSPHATE AND L-SER BOUND AS AMINO ACRYLATE TO THE BETA SITE'''<br />
{{Structure
|PDB= 1a5s |SIZE=350|CAPTION= <scene name='initialview01'>1a5s</scene>, resolution 2.30&Aring;
|SITE= <scene name='pdbsite=S1:Substrate+Analog+Bound+To+The+Alpha+Active+Site'>S1</scene> and <scene name='pdbsite=S2:Reaction+Intermediate+Bound+To+The+Beta+Active+Site'>S2</scene>
|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=FIP:5-FLUOROINDOLE+PROPANOL+PHOSPHATE'>FIP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5'-PHOSPHATE'>PLP</scene> and <scene name='pdbligand=SER:SERINE'>SER</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20]
|GENE= TRPA/TRPB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=602 Salmonella typhimurium])
}}
 
'''CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUOROINDOLE PROPANOL PHOSPHATE AND L-SER BOUND AS AMINO ACRYLATE TO THE BETA SITE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1A5S is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium] with <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=FIP:'>FIP</scene>, <scene name='pdbligand=PLP:'>PLP</scene> and <scene name='pdbligand=SER:'>SER</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] Known structural/functional Sites: <scene name='pdbsite=S1:Substrate+Analog+Bound+To+The+Alpha+Active+Site'>S1</scene> and <scene name='pdbsite=S2:Reaction+Intermediate+Bound+To+The+Beta+Active+Site'>S2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5S OCA].  
1A5S is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5S OCA].  


==Reference==
==Reference==
Loop closure and intersubunit communication in tryptophan synthase., Schneider TR, Gerhardt E, Lee M, Liang PH, Anderson KS, Schlichting I, Biochemistry. 1998 Apr 21;37(16):5394-406. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9548921 9548921]
Loop closure and intersubunit communication in tryptophan synthase., Schneider TR, Gerhardt E, Lee M, Liang PH, Anderson KS, Schlichting I, Biochemistry. 1998 Apr 21;37(16):5394-406. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9548921 9548921]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Salmonella typhimurium]]
[[Category: Salmonella typhimurium]]
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[[Category: tryptophan biosynthesis]]
[[Category: tryptophan biosynthesis]]


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