Sandbox Reserved 930: Difference between revisions

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[[Image:Actin myosin anim.gif|400px|left|thumb| Figure 1. The movement of myosin motor domain on actin filament.<ref> San Diego State University College of Sciences, ''[http://www.sci.sdsu.edu/movies/actin_myosin_gif.html link]''</ref>]]

[[Image:myosin.png‎|450px|right|thumb| Figure 2. The contractile cycle of the myosin head <ref name=Krans2010>Krans, J. 2010. [http://www.nature.com/scitable/topicpage/the-sliding-filament-theory-of-muscle-contraction-14567666 The Sliding Filament Theory of Muscle Contraction.] Nature Education 3(9):66. </ref>.]]

In the striated muscle the actin and myosin proteins form ordered basic units called sarcomeres. Muscle contraction is achieved by the mechanical sliding of myosin filament (thick filament) along the actin filament (thin filament), Fig. 1. The major constituent of the myosin filament is myosin, a motor protein responsible for converting chemical energy to mechanical movement. In the presence of Ca2+ and Mg2+ myosin is able to cyclically bind ATP and hydrolyse it to ADP + Pi , thus triggering myosin-actin detachment, reattachment and power stroke, the so called contractile ~~reaction~~ (Fig.2)<ref name=Krans2010 />.

In the striated muscle the actin and myosin proteins form ordered basic units called sarcomeres. Muscle contraction is achieved by the mechanical sliding of myosin filament (thick filament) along the actin filament (thin filament), Fig. 1. The major constituent of the myosin filament is myosin, a motor protein responsible for converting chemical energy to mechanical movement. In the presence of Ca2+ and Mg2+ myosin is able to cyclically bind ATP and hydrolyse it to ADP + Pi , thus triggering myosin-actin detachment, reattachment and power stroke, the so called contractile cycle (Fig.2)<ref name=Krans2010 />.

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   [[Image:Actin myosin anim.gif|400px|left|thumb| Figure 1. The movement of myosin motor domain on actin filament.<ref> San Diego State University College of Sciences, ''[http://www.sci.sdsu.edu/movies/actin_myosin_gif.html link]''</ref>]]
 [[Image:myosin.png‎|450px|right|thumb| Figure 2. The contractile cycle of the myosin head <ref name=Krans2010>Krans, J. 2010. [http://www.nature.com/scitable/topicpage/the-sliding-filament-theory-of-muscle-contraction-14567666 The Sliding Filament Theory of Muscle Contraction.] Nature Education 3(9):66. </ref>.]]
-In the striated muscle the actin and myosin proteins form ordered basic units called sarcomeres. Muscle contraction is achieved by the mechanical sliding of myosin filament (thick filament) along the actin filament (thin filament), Fig. 1. The major constituent of the myosin filament is myosin, a motor protein responsible for converting chemical energy to mechanical movement. In the presence of Ca<sup>2+</sup> and Mg<sup>2+</sup> myosin is able to cyclically bind ATP and hydrolyse it to ADP + P<sub>i</sub> , thus triggering myosin-actin detachment, reattachment and power stroke, the so called contractile reaction (Fig.2)<ref name=Krans2010 />.
+In the striated muscle the actin and myosin proteins form ordered basic units called sarcomeres. Muscle contraction is achieved by the mechanical sliding of myosin filament (thick filament) along the actin filament (thin filament), Fig. 1. The major constituent of the myosin filament is myosin, a motor protein responsible for converting chemical energy to mechanical movement. In the presence of Ca<sup>2+</sup> and Mg<sup>2+</sup> myosin is able to cyclically bind ATP and hydrolyse it to ADP + P<sub>i</sub> , thus triggering myosin-actin detachment, reattachment and power stroke, the so called contractile cycle (Fig.2)<ref name=Krans2010 />.