3kmo: Difference between revisions

Line 1:

~~[[Image:3kmo.png|left|200px]]~~

==Crystal Structure of the Human GST Pi C47S/Y108V Double Mutant in Complex with the Ethacrynic Acid-Glutathione Conjugate (Grown in the Absence of the Reducing Agent DTT)==

~~<!--~~

== Structural highlights ==

~~The line below this paragraph, containing "STRUCTURE_3kmo", creates the "Structure Box" on the page.~~

<table><tr><td colspan='2'>[[3kmo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KMO FirstGlance]. <br>

~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~

</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EAA:ETHACRYNIC+ACID'>EAA</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene><br>

~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~

<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3km6|3km6]], [[3kmn|3kmn]]</td></tr>

~~or leave the SCENE parameter empty for the default display.~~

<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FAEES3, GST3, GSTP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>

~~-->~~

<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>

~~{{STRUCTURE_3kmo| PDB=3kmo | SCENE= }}~~

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kmo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kmo RCSB], [http://www.ebi.ac.uk/pdbsum/3kmo PDBsum]</span></td></tr>

<table>

===Crystal Structure of the Human GST Pi C47S/Y108V Double Mutant in Complex with the Ethacrynic Acid-Glutathione Conjugate (Grown in the Absence of the Reducing Agent DTT)===

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

Check<jmol>

<~~!--~~

~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_020540076}}, adds the Publication Abstract to the page~~

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/3kmo_consurf.spt"</scriptWhenChecked>

~~(as it appears on PubMed at http://www~~.~~pubmed.gov), where 020540076 is the PubMed ID number.~~

<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>

-->

<text>to colour the structure by Evolutionary Conservation</text>

~~{{ABSTRACT_PUBMED_020540076}}~~

</jmolCheckbox>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].

==~~About this Structure~~==

[[3kmo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KMO OCA].

__TOC__

</StructureSection>

==~~Reference~~==

<~~ref group~~="~~xtra~~">~~PMID~~:~~020540076~~</~~ref~~><~~references group~~="~~xtra~~"/>

[[Category: Glutathione transferase]]

[[Category: Homo sapiens]]

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@@ Line 1: / Line 1: @@
-[[Image:3kmo.png|left|200px]]
+==Crystal Structure of the Human GST Pi C47S/Y108V Double Mutant in Complex with the Ethacrynic Acid-Glutathione Conjugate (Grown in the Absence of the Reducing Agent DTT)==
+<StructureSection load='3kmo' size='340' side='right' caption='[[3kmo]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-<!--
+== Structural highlights ==
-The line below this paragraph, containing "STRUCTURE_3kmo", creates the "Structure Box" on the page.
+<table><tr><td colspan='2'>[[3kmo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KMO FirstGlance]. <br>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EAA:ETHACRYNIC+ACID'>EAA</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene><br>
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3km6|3km6]], [[3kmn|3kmn]]</td></tr>
-or leave the SCENE parameter empty for the default display.
+<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FAEES3, GST3, GSTP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
--->
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
-{{STRUCTURE_3kmo|  PDB=3kmo  |  SCENE=  }}
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kmo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kmo RCSB], [http://www.ebi.ac.uk/pdbsum/3kmo PDBsum]</span></td></tr>
+<table>
-===Crystal Structure of the Human GST Pi C47S/Y108V Double Mutant in Complex with the Ethacrynic Acid-Glutathione Conjugate (Grown in the Absence of the Reducing Agent DTT)===
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
-<!--
+  <jmolCheckbox>
-The line below this paragraph, {{ABSTRACT_PUBMED_020540076}}, adds the Publication Abstract to the page
+    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/3kmo_consurf.spt"</scriptWhenChecked>
-(as it appears on PubMed at http://www.pubmed.gov), where 020540076 is the PubMed ID number.
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
--->
+    <text>to colour the structure by Evolutionary Conservation</text>
-{{ABSTRACT_PUBMED_020540076}}
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
-==About this Structure==
+<div style="clear:both"></div>
-[[3kmo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KMO OCA].
+__TOC__
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:020540076</ref><references group="xtra"/>
 [[Category: Glutathione transferase]]
 [[Category: Homo sapiens]]