1ah8: Difference between revisions
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[[Image:1ah8.gif|left|200px]] | [[Image:1ah8.gif|left|200px]] | ||
'''STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE''' | {{Structure | ||
|PDB= 1ah8 |SIZE=350|CAPTION= <scene name='initialview01'>1ah8</scene>, resolution 2.10Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1AH8 is a [ | 1AH8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AH8 OCA]. | ||
==Reference== | ==Reference== | ||
A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone., Prodromou C, Roe SM, Piper PW, Pearl LH, Nat Struct Biol. 1997 Jun;4(6):477-82. PMID:[http:// | A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone., Prodromou C, Roe SM, Piper PW, Pearl LH, Nat Struct Biol. 1997 Jun;4(6):477-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9187656 9187656] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: heat shock]] | [[Category: heat shock]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:57:31 2008'' | ||
Revision as of 07:57, 20 March 2008
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| 1ah8, resolution 2.10Å | |||||||||||||
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| Ligands: | GOL | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Overview
Hsp90 is a highly specific chaperone for many signal transduction proteins, including steroid hormone receptors and a broad range of protein kinases. The crystal structure of the N-terminal domain of the yeast Hsp90 reveals a dimeric structure based on a highly twisted sixteen stranded beta-sheet, whose topology suggests a possible 30-domain-swapped structure for the intact Hsp90 dimer. The opposing faces of the beta-sheets in the dimer define a potential peptide-binding cleft, suggesting that the N-domain may serve as a molecular 'clamp' in the binding of ligand proteins to Hsp90.
About this Structure
1AH8 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone., Prodromou C, Roe SM, Piper PW, Pearl LH, Nat Struct Biol. 1997 Jun;4(6):477-82. PMID:9187656
Page seeded by OCA on Thu Mar 20 09:57:31 2008
