3mpg: Difference between revisions

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[[~~Image~~:~~3mpg~~.~~png~~|~~left~~|~~200px~~]]

==Dihydroorotase from Bacillus anthracis==

== Structural highlights ==

<table><tr><td colspan='2'>[[3mpg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MPG FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>

<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAS3739, BA_4027, GBAA_4027, pyrC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])</td></tr>

<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotase Dihydroorotase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.3 3.5.2.3] </span></td></tr>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mpg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mpg RCSB], [http://www.ebi.ac.uk/pdbsum/3mpg PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

Dihydroorotase (EC 3.5.2.3) catalyzes the reversible cyclization of N-carbamoyl-L-aspartate to L-dihydroorotate in the third step of the pyrimidine-biosynthesis pathway in Bacillus anthracis. A comparison is made between the structures of dihydroorotase from four different organisms, including B. anthracis dihydroorotase, and reveals substantial variations in the active site, dimer interface and overall tertiary structure. These differences demonstrate the utility of exploring multiple structures of a molecular target as expressed from different organisms and how these differences can be exploited for structure-based drug discovery.

~~<!--~~

Structure of dihydroorotase from Bacillus anthracis at 2.6 A resolution.,Mehboob S, Mulhearn DC, Truong K, Johnson ME, Santarsiero BD Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt, 11):1432-5. Epub 2010 Oct 27. PMID:21045288<ref>PMID:21045288</ref>

~~The line below this paragraph~~, ~~containing "STRUCTURE_3mpg"~~, ~~creates the "Structure Box" on the page~~.

~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)

~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~

~~or leave the SCENE parameter empty for the default display~~.

-->

~~{{STRUCTURE_3mpg| PDB=3mpg | SCENE= }}~~

~~===Dihydroorotase from Bacillus anthracis===~~

From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>

</div>

== References ==

~~<!--~~

~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21045288}}, adds the Publication Abstract to~~ the ~~page~~

__TOC__

~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21045288 is the PubMed ID number~~.

</StructureSection>

-->

~~{{ABSTRACT_PUBMED_21045288}}~~

~~==About this Structure==~~

~~[[3mpg]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPG OCA].~~

==~~Reference~~==

<~~ref group="xtra">PMID:021045288<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Bacillus anthracis]]

[[Category: Dihydroorotase]]

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@@ Line 1: / Line 1: @@
-[[Image:3mpg.png|left|200px]]
+==Dihydroorotase from Bacillus anthracis==
+<StructureSection load='3mpg' size='340' side='right' caption='[[3mpg]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3mpg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MPG FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
+<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAS3739, BA_4027, GBAA_4027, pyrC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])</td></tr>
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotase Dihydroorotase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.3 3.5.2.3] </span></td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mpg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mpg RCSB], [http://www.ebi.ac.uk/pdbsum/3mpg PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Dihydroorotase (EC 3.5.2.3) catalyzes the reversible cyclization of N-carbamoyl-L-aspartate to L-dihydroorotate in the third step of the pyrimidine-biosynthesis pathway in Bacillus anthracis. A comparison is made between the structures of dihydroorotase from four different organisms, including B. anthracis dihydroorotase, and reveals substantial variations in the active site, dimer interface and overall tertiary structure. These differences demonstrate the utility of exploring multiple structures of a molecular target as expressed from different organisms and how these differences can be exploited for structure-based drug discovery.
-<!--
+Structure of dihydroorotase from Bacillus anthracis at 2.6 A resolution.,Mehboob S, Mulhearn DC, Truong K, Johnson ME, Santarsiero BD Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt, 11):1432-5. Epub 2010 Oct 27. PMID:21045288<ref>PMID:21045288</ref>
-The line below this paragraph, containing "STRUCTURE_3mpg", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
-{{STRUCTURE_3mpg|  PDB=3mpg  |  SCENE=  }}
-===Dihydroorotase from Bacillus anthracis===
+From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+</div>
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_21045288}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 21045288 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_21045288}}
-==About this Structure==
-[[3mpg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPG OCA].
-==Reference==
-<ref group="xtra">PMID:021045288</ref><references group="xtra"/>
 [[Category: Bacillus anthracis]]
 [[Category: Dihydroorotase]]