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| {{STRUCTURE_4cjy| PDB=4cjy | SCENE= }}
| | #REDIRECT [[4un0]] This PDB entry is obsolete and replaced by 4un0 |
| ===Crystal structure of the human CDK12-cyclinK complex===
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| ==Disease==
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| [[http://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN]] Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2. | |
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| ==Function==
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| [[http://www.uniprot.org/uniprot/CCNK_HUMAN CCNK_HUMAN]] May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK).<ref>PMID:10574912</ref> [[http://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN]] Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors.<ref>PMID:11683387</ref> <ref>PMID:19651820</ref> <ref>PMID:20952539</ref>
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| ==About this Structure==
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| [[4cjy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CJY OCA].
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| ==Reference==
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| <references group="xtra"/><references/>
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| [[Category: Cyclin-dependent kinase]]
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| [[Category: Arrowsmith, C H.]]
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| [[Category: Bountra, C.]]
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| [[Category: Bullock, A.]]
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| [[Category: Burgess-Brown, N.]]
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| [[Category: Carpenter, E P.]]
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| [[Category: Chaikuad, A.]]
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| [[Category: Clarke, S E.Dixon.]]
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| [[Category: Delft, F von.]]
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| [[Category: Edwards, A M.]]
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| [[Category: Elkins, J M.]]
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| [[Category: Goubin, S.]]
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| [[Category: Knapp, S.]]
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| [[Category: Kopec, J.]]
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| [[Category: Krojer, T.]]
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| [[Category: Mahajan, R P.]]
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| [[Category: Nowak, R.]]
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| [[Category: Pike, A C.W.]]
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| [[Category: Sorrell, F J.]]
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| [[Category: Williams, E.]]
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| [[Category: Kinase]]
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| [[Category: Transferase]]
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