3rjo: Difference between revisions

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[[Image:3rjo.png|left|200px]]
==Crystal Structure of ERAP1 Peptide Binding Domain==
<StructureSection load='3rjo' size='340' side='right' caption='[[3rjo]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3rjo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RJO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RJO FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ERAP1, APPILS, ARTS1, KIAA0525, UNQ584/PRO1154 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rjo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rjo RCSB], [http://www.ebi.ac.uk/pdbsum/3rjo PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an essential component of the immune system, because it trims peptide precursors and generates the N--restricted epitopes. To examine ERAP1's unique properties of length- and sequence-dependent processing of antigen precursors, we report a 2.3 A resolution complex structure of the ERAP1 regulatory domain. Our study reveals a binding conformation of ERAP1 to the carboxyl terminus of a peptide, and thus provides direct evidence for the molecular ruler mechanism.


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Structural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1.,Gandhi A, Lakshminarasimhan D, Sun Y, Guo HC Sci Rep. 2011;1:186. Epub 2011 Dec 13. PMID:22355701<ref>PMID:22355701</ref>
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{{STRUCTURE_3rjo|  PDB=3rjo  |  SCENE=  }}


===Crystal Structure of ERAP1 Peptide Binding Domain===
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>


 
==See Also==
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*[[Aminopeptidase|Aminopeptidase]]
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== References ==
(as it appears on PubMed at http://www.pubmed.gov), where 22355701 is the PubMed ID number.
<references/>
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{{ABSTRACT_PUBMED_22355701}}
</StructureSection>
 
==About this Structure==
[[3rjo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RJO OCA].
 
==Reference==
<ref group="xtra">PMID:022355701</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Gandhi, A.]]
[[Category: Gandhi, A.]]

Revision as of 04:54, 5 June 2014

Crystal Structure of ERAP1 Peptide Binding Domain

3rjo, resolution 2.30Å

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