3s32: Difference between revisions

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[[Image:3s32.png|left|200px]]
==Crystal structure of Ash2L N-terminal domain==
<StructureSection load='3s32' size='340' side='right' caption='[[3s32]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3s32]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S32 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ASH2L, ASH2L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s32 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s32 RCSB], [http://www.ebi.ac.uk/pdbsum/3s32 PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Absent, small or homeotic discs-like 2 (ASH2L) is a trithorax group (TrxG) protein and a regulatory subunit of the SET1 family of lysine methyltransferases. Here we report that ASH2L binds DNA using a forkhead-like helix-wing-helix (HWH) domain. In vivo, the ASH2L HWH domain is required for binding to the beta-globin locus control region, histone H3 Lys4 (H3K4) trimethylation and maximal expression of the beta-globin gene (Hbb-1), validating the functional importance of the ASH2L DNA binding domain.


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Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain.,Sarvan S, Avdic V, Tremblay V, Chaturvedi CP, Zhang P, Lanouette S, Blais A, Brunzelle JS, Brand M, Couture JF Nat Struct Mol Biol. 2011 Jun 5;18(7):857-9. doi: 10.1038/nsmb.2093. PMID:21642971<ref>PMID:21642971</ref>
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{{STRUCTURE_3s32|  PDB=3s32  |  SCENE=  }}


===Crystal structure of Ash2L N-terminal domain===
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>


 
==See Also==
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*[[Histone methyltransferase|Histone methyltransferase]]
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== References ==
(as it appears on PubMed at http://www.pubmed.gov), where 21642971 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21642971}}
</StructureSection>
 
==About this Structure==
[[3s32]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S32 OCA].
 
==Reference==
<ref group="xtra">PMID:021642971</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Avdic, V.]]
[[Category: Avdic, V.]]
Retrieved from "https://proteopedia.org/3s32"