3s34: Difference between revisions

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[[Image:3s34.jpg|left|200px]]
==Structure of the 1121B Fab fragment==
<StructureSection load='3s34' size='340' side='right' caption='[[3s34]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3s34]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S34 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S34 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3s37|3s37]], [[3s36|3s36]]</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s34 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s34 RCSB], [http://www.ebi.ac.uk/pdbsum/3s34 PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The anti-VEGF receptor 2 antibody IMC-1121B is a promising antiangiogenic drug being tested for treatment of breast and gastric cancer. We have determined the structure of the 1121B Fab fragment in complex with domain 3 of VEGFR2, as well as the structure of a different neutralizing anti-VEGFR2 antibody, 6.64, also in complex with VEGFR2 domain 3. The two Fab fragments bind at opposite ends of VEGFR2 domain 3; 1121B directly blocks VEGF binding, whereas 6.64 may prevent receptor dimerization by perturbing the domain 3:domain 4 interface. Mutagenesis reveals that residues essential for VEGF, 1121B, and 6.64 binding are nonoverlapping among the three contact patches.


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The Structural Basis for the Function of Two Anti-VEGF Receptor 2 Antibodies.,Franklin MC, Navarro EC, Wang Y, Patel S, Singh P, Zhang Y, Persaud K, Bari A, Griffith H, Shen L, Balderes P, Kussie P Structure. 2011 Aug 10;19(8):1097-107. PMID:21827946<ref>PMID:21827946</ref>
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{{STRUCTURE_3s34|  PDB=3s34  |  SCENE=  }}


===Structure of the 1121B Fab fragment===
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
 
</div>
 
== References ==
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[[Category: Lk3 transgenic mice]]
{{ABSTRACT_PUBMED_21827946}}
 
==About this Structure==
[[3s34]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus,_homo_sapiens Mus musculus, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S34 OCA].
 
==Reference==
<ref group="xtra">PMID:021827946</ref><references group="xtra"/>
[[Category: Mus musculus, homo sapiens]]
[[Category: Franklin, M C.]]
[[Category: Franklin, M C.]]
[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Vegf receptor domain 3]]
[[Category: Vegf receptor domain 3]]
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