1b15: Difference between revisions

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[[Image:1b15.gif|left|200px]]<br /><applet load="1b15" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1b15.gif|left|200px]]
caption="1b15, resolution 2.2&Aring;" />
 
'''ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS TERNARY COMPLEX WITH NAD-ACETONE'''<br />
{{Structure
|PDB= 1b15 |SIZE=350|CAPTION= <scene name='initialview01'>1b15</scene>, resolution 2.2&Aring;
|SITE= <scene name='pdbsite=ACA:Catalytic+Triad'>ACA</scene>, <scene name='pdbsite=ACB:Catalytic+Triad'>ACB</scene>, <scene name='pdbsite=CAA:Ca2++Binding+Residues'>CAA</scene>, <scene name='pdbsite=CAB:Ca2++Binding+Residues'>CAB</scene>, <scene name='pdbsite=NA1:Nad+Binding+Motif+In+Dadhs+G(A)Xgxxg'>NA1</scene>, <scene name='pdbsite=NA2:Nad+Binding+Motif+In+Sdrs+Gxxxgxg'>NA2</scene>, <scene name='pdbsite=NA3:Nad/Nadp+Selectivity+Amino+Acid'>NA3</scene>, <scene name='pdbsite=NB1:Nad+Binding+Motif+In+Dadhs+G(A)Xgxxg'>NB1</scene>, <scene name='pdbsite=NB2:Nad+Binding+Motif+In+Sdrs+Gxxxgxg'>NB2</scene> and <scene name='pdbsite=NB3:Nad/Nadp+Selectivity+Amino+Acid'>NB3</scene>
|LIGAND= <scene name='pdbligand=NAE:NICOTINAMIDE ADENINE DINUCLEOTIDE ACETONE ADDUCT'>NAE</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1]
|GENE=
}}
 
'''ALCOHOL DEHYDROGENASE FROM DROSOPHILA LEBANONENSIS TERNARY COMPLEX WITH NAD-ACETONE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1B15 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis] with <scene name='pdbligand=NAE:'>NAE</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] Known structural/functional Sites: <scene name='pdbsite=ACA:Catalytic+Triad'>ACA</scene>, <scene name='pdbsite=ACB:Catalytic+Triad'>ACB</scene>, <scene name='pdbsite=CAA:Ca2++Binding+Residues'>CAA</scene>, <scene name='pdbsite=CAB:Ca2++Binding+Residues'>CAB</scene>, <scene name='pdbsite=NA1:Nad+Binding+Motif+In+Dadhs+G(A)Xgxxg'>NA1</scene>, <scene name='pdbsite=NA2:Nad+Binding+Motif+In+Sdrs+Gxxxgxg'>NA2</scene>, <scene name='pdbsite=NA3:Nad/Nadp+Selectivity+Amino+Acid'>NA3</scene>, <scene name='pdbsite=NB1:Nad+Binding+Motif+In+Dadhs+G(A)Xgxxg'>NB1</scene>, <scene name='pdbsite=NB2:Nad+Binding+Motif+In+Sdrs+Gxxxgxg'>NB2</scene> and <scene name='pdbsite=NB3:Nad/Nadp+Selectivity+Amino+Acid'>NB3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B15 OCA].  
1B15 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Scaptodrosophila_lebanonensis Scaptodrosophila lebanonensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B15 OCA].  


==Reference==
==Reference==
The catalytic reaction and inhibition mechanism of Drosophila alcohol dehydrogenase: observation of an enzyme-bound NAD-ketone adduct at 1.4 A resolution by X-ray crystallography., Benach J, Atrian S, Gonzalez-Duarte R, Ladenstein R, J Mol Biol. 1999 Jun 4;289(2):335-55. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10366509 10366509]
The catalytic reaction and inhibition mechanism of Drosophila alcohol dehydrogenase: observation of an enzyme-bound NAD-ketone adduct at 1.4 A resolution by X-ray crystallography., Benach J, Atrian S, Gonzalez-Duarte R, Ladenstein R, J Mol Biol. 1999 Jun 4;289(2):335-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10366509 10366509]
[[Category: Alcohol dehydrogenase]]
[[Category: Alcohol dehydrogenase]]
[[Category: Scaptodrosophila lebanonensis]]
[[Category: Scaptodrosophila lebanonensis]]
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[[Category: nad- acetone adduct]]
[[Category: nad- acetone adduct]]
[[Category: oxidoreductase]]
[[Category: oxidoreductase]]
[[Category: short-chain dehydrogenases/reductases]]
[[Category: short-chain dehydrogenases/reductase]]
[[Category: ternary complex]]
[[Category: ternary complex]]


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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:04:59 2008''
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