3t9i: Difference between revisions

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[[Image:3t9i.png|left|200px]]
==Pim1 complexed with a novel 3,6-disubstituted indole at 2.6 Ang Resolution==
<StructureSection load='3t9i' size='340' side='right' caption='[[3t9i]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3t9i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T9I FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3T9:2-METHOXY-4-(3-PHENYL-2H-PYRAZOLO[3,4-B]PYRIDIN-6-YL)PHENOL'>3T9</scene><br>
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t9i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t9i RCSB], [http://www.ebi.ac.uk/pdbsum/3t9i PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A series of novel 3,5-disubstituted indole derivatives as potent and selective inhibitors of all three members of the Pim kinase family is described. High throughput screen identified a pan-Pim kinase inhibitor with a promiscuous scaffold. Guided by structure-based drug design, SAR of the series afforded a highly selective indole chemotype that was further developed into a potent set of compounds against Pim-1, 2, and 3 (Pim-1 and Pim-3: IC(50)&lt;/=2nM and Pim-2: IC(50)&lt;/=100nM).


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Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases.,Nishiguchi GA, Atallah G, Bellamacina C, Burger MT, Ding Y, Feucht PH, Garcia PD, Han W, Klivansky L, Lindvall M Bioorg Med Chem Lett. 2011 Nov 1;21(21):6366-9. Epub 2011 Sep 10. PMID:21945284<ref>PMID:21945284</ref>
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{{STRUCTURE_3t9i|  PDB=3t9i  |  SCENE=  }}


===Pim1 complexed with a novel 3,6-disubstituted indole at 2.6 Ang Resolution===
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>


 
==See Also==
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*[[Proto-oncogene serine/threonine-protein kinase|Proto-oncogene serine/threonine-protein kinase]]
The line below this paragraph, {{ABSTRACT_PUBMED_21945284}}, adds the Publication Abstract to the page
== References ==
(as it appears on PubMed at http://www.pubmed.gov), where 21945284 is the PubMed ID number.
<references/>
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{{ABSTRACT_PUBMED_21945284}}
</StructureSection>
 
==About this Structure==
[[3t9i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T9I OCA].
 
==Reference==
<ref group="xtra">PMID:021945284</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]

Revision as of 06:14, 5 June 2014

Pim1 complexed with a novel 3,6-disubstituted indole at 2.6 Ang Resolution

3t9i, resolution 2.60Å

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