3u2f: Difference between revisions

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[[Image:3u2f.png|left|200px]]
==ATP synthase c10 ring in proton-unlocked conformation at PH 8.3==
<StructureSection load='3u2f' size='340' side='right' caption='[[3u2f]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3u2f]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U2F FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xok|2xok]], [[2xqu|2xqu]], [[2x2v|2x2v]], [[2wgm|2wgm]], [[3u2y|3u2y]], [[3u32|3u32]]</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u2f RCSB], [http://www.ebi.ac.uk/pdbsum/3u2f PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The proton pore of the F(1)F(o) ATP synthase consists of a ring of c subunits, which rotates, driven by downhill proton diffusion across the membrane. An essential carboxylate side chain in each subunit provides a proton-binding site. In all the structures of c-rings reported to date, these sites are in a closed, ion-locked state. Structures are here presented of the c(10) ring from Saccharomyces cerevisiae determined at pH 8.3, 6.1 and 5.5, at resolutions of 2.0 A, 2.5 A and 2.0 A, respectively. The overall structure of this mitochondrial c-ring is similar to known homologs, except that the essential carboxylate, Glu59, adopts an open extended conformation. Molecular dynamics simulations reveal that opening of the essential carboxylate is a consequence of the amphiphilic nature of the crystallization buffer. We propose that this new structure represents the functionally open form of the c subunit, which facilitates proton loading and release.


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Structure of the c(10) ring of the yeast mitochondrial ATP synthase in the open conformation.,Symersky J, Pagadala V, Osowski D, Krah A, Meier T, Faraldo-Gomez JD, Mueller DM Nat Struct Mol Biol. 2012 Apr 15;19(5):485-91. doi: 10.1038/nsmb.2284. PMID:22504883<ref>PMID:22504883</ref>
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{{STRUCTURE_3u2f|  PDB=3u2f  |  SCENE=  }}


===ATP synthase c10 ring in proton-unlocked conformation at PH 8.3===
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>


 
==See Also==
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*[[ATP synthase|ATP synthase]]
The line below this paragraph, {{ABSTRACT_PUBMED_22504883}}, adds the Publication Abstract to the page
*[[ATPase|ATPase]]
(as it appears on PubMed at http://www.pubmed.gov), where 22504883 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_22504883}}
__TOC__
 
</StructureSection>
==About this Structure==
[[3u2f]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2F OCA].
 
==Reference==
<ref group="xtra">PMID:022504883</ref><references group="xtra"/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Faraldo-Gomez, J.]]
[[Category: Faraldo-Gomez, J.]]

Revision as of 06:35, 5 June 2014

ATP synthase c10 ring in proton-unlocked conformation at PH 8.3

3u2f, resolution 2.00Å

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