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[[Image:3tgb.jpg|left|200px]]
==Crystal structure of L130R mutant of Nitrophorin 4 from Rhodnius prolixus complexed with imidazole at pH 7.4==
<StructureSection load='3tgb' size='340' side='right' caption='[[3tgb]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3tgb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TGB FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene><br>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tga|3tga]], [[3tgc|3tgc]]</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tgb RCSB], [http://www.ebi.ac.uk/pdbsum/3tgb PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Prestidigitation: In a mutant of the heme protein nitrophorin 4, the first binding of guanidine to iron in a porphyrin is observed. The protein pocket has two effects that aid this binding: its overall structure holds the ligands together providing binding energy from the chelate effect and it facilitates the deprotonation of the highly basic guanidine residue.


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Guanidine-Ferroheme Coordination in the Mutant Protein Nitrophorin 4(L130R).,He C, Fuchs MR, Ogata H, Knipp M Angew Chem Int Ed Engl. 2012 Apr 27;51(18):4470-3. doi: 10.1002/anie.201108691., Epub 2012 Feb 14. PMID:22334402<ref>PMID:22334402</ref>
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{{STRUCTURE_3tgb|  PDB=3tgb  |  SCENE=  }}


===Crystal structure of L130R mutant of Nitrophorin 4 from Rhodnius prolixus complexed with imidazole at pH 7.4===
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
 
</div>
 
== References ==
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<references/>
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{{ABSTRACT_PUBMED_22334402}}
 
==About this Structure==
[[3tgb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGB OCA].
 
==Reference==
<ref group="xtra">PMID:022334402</ref><references group="xtra"/>
[[Category: Rhodnius prolixus]]
[[Category: Rhodnius prolixus]]
[[Category: He, C.]]
[[Category: He, C.]]

Revision as of 06:45, 5 June 2014

Crystal structure of L130R mutant of Nitrophorin 4 from Rhodnius prolixus complexed with imidazole at pH 7.4

3tgb, resolution 1.35Å

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