4er0: Difference between revisions

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[[~~Image~~:~~4er0~~.~~jpg~~|~~left~~|~~200px~~]]

==Crystal Structure of human DOT1L in complex with inhibitor FED1==

== Structural highlights ==

<table><tr><td colspan='2'>[[4er0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER0 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ER0 FirstGlance].

</td></tr><tr><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=AW1:5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(PROPAN-2-YL)AMINO]-5-DEOXYADENOSINE'>AW1</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>

<tr><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">DOT1L, KIAA1814, KMT4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>

<tr><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </td></tr>

<tr><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4er0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4er0 RCSB], [http://www.ebi.ac.uk/pdbsum/4er0 PDBsum]</td></tr>

<table>

~~<!--~~

==See Also==

~~The line below this paragraph, containing "STRUCTURE_4er0", creates the "Structure Box" on the page.~~

*[[Histone methyltransferase|Histone methyltransferase]]

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__TOC__

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</StructureSection>

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~~{{STRUCTURE_4er0| PDB=4er0 | SCENE= }}~~

~~===Crystal Structure of human DOT1L in complex with inhibitor FED1===~~

==~~About this Structure~~==

[[~~4er0~~]] ~~is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER0 OCA].~~

[[Category: Histone-lysine N-methyltransferase]]

[[Category: Homo sapiens]]

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-[[Image:4er0.jpg|left|200px]]
+==Crystal Structure of human DOT1L in complex with inhibitor FED1==
+<StructureSection load='4er0' size='340' side='right' caption='[[4er0]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4er0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ER0 FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AW1:5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(PROPAN-2-YL)AMINO]-5-DEOXYADENOSINE'>AW1</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene><br>
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eqz|4eqz]], [[4er3|4er3]], [[4er5|4er5]], [[4er6|4er6]], [[4er7|4er7]]</td></tr>
+<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DOT1L, KIAA1814, KMT4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4er0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4er0 RCSB], [http://www.ebi.ac.uk/pdbsum/4er0 PDBsum]</span></td></tr>
+<table>
-<!--
+==See Also==
-The line below this paragraph, containing "STRUCTURE_4er0", creates the "Structure Box" on the page.
+*[[Histone methyltransferase|Histone methyltransferase]]
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+__TOC__
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+</StructureSection>
-or leave the SCENE parameter empty for the default display.
--->
-{{STRUCTURE_4er0|  PDB=4er0  |  SCENE=  }}
-===Crystal Structure of human DOT1L in complex with inhibitor FED1===
-==About this Structure==
-[[4er0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER0 OCA].
 [[Category: Histone-lysine N-methyltransferase]]
 [[Category: Homo sapiens]]