4dg6: Difference between revisions

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~~[[Image:4dg6.jpg|left|200px]]~~

==Crystal structure of domains 1 and 2 of LRP6==

~~<!--~~

== Structural highlights ==

~~The line below this paragraph, containing "STRUCTURE_4dg6", creates the "Structure Box" on the page.~~

<table><tr><td colspan='2'>[[4dg6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DG6 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DG6 FirstGlance].

~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~

</td></tr><tr><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>

~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~

<tr><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">LRP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>

~~or leave the SCENE parameter empty for the default display.~~

<tr><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dg6 RCSB], [http://www.ebi.ac.uk/pdbsum/4dg6 PDBsum]</td></tr>

~~-->~~

<table>

~~{{STRUCTURE_4dg6| PDB=4dg6 | SCENE= }}~~

== Disease ==

[[http://www.uniprot.org/uniprot/LRP6_HUMAN LRP6_HUMAN]] Coronary artery disease - hyperlipidemia - hypertension - diabetes - osteoporosis. The disease is caused by mutations affecting the gene represented in this entry.

===Crystal structure of domains 1 and 2 of LRP6===

== Function ==

[[http://www.uniprot.org/uniprot/LRP6_HUMAN LRP6_HUMAN]] Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).<ref>PMID:11448771</ref> <ref>PMID:11357136</ref> <ref>PMID:15778503</ref> <ref>PMID:16341017</ref> <ref>PMID:16513652</ref> <ref>PMID:17400545</ref> <ref>PMID:17326769</ref> <ref>PMID:19107203</ref> <ref>PMID:19801552</ref> <ref>PMID:19293931</ref>

== References ==

==~~About this Structure~~==

[[4dg6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DG6 OCA].

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Ceska, T A.]]

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@@ Line 1: / Line 1: @@
-[[Image:4dg6.jpg|left|200px]]
+==Crystal structure of domains 1 and 2 of LRP6==
+<StructureSection load='4dg6' size='340' side='right' caption='[[4dg6]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-<!--
+== Structural highlights ==
-The line below this paragraph, containing "STRUCTURE_4dg6", creates the "Structure Box" on the page.
+<table><tr><td colspan='2'>[[4dg6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DG6 FirstGlance]. <br>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LRP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-or leave the SCENE parameter empty for the default display.
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dg6 RCSB], [http://www.ebi.ac.uk/pdbsum/4dg6 PDBsum]</span></td></tr>
--->
+<table>
-{{STRUCTURE_4dg6|  PDB=4dg6  |  SCENE=  }}
+== Disease ==
+[[http://www.uniprot.org/uniprot/LRP6_HUMAN LRP6_HUMAN]] Coronary artery disease - hyperlipidemia - hypertension - diabetes - osteoporosis. The disease is caused by mutations affecting the gene represented in this entry.
-===Crystal structure of domains 1 and 2 of LRP6===
+== Function ==
+[[http://www.uniprot.org/uniprot/LRP6_HUMAN LRP6_HUMAN]] Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).<ref>PMID:11448771</ref> <ref>PMID:11357136</ref> <ref>PMID:15778503</ref> <ref>PMID:16341017</ref> <ref>PMID:16513652</ref> <ref>PMID:17400545</ref> <ref>PMID:17326769</ref> <ref>PMID:19107203</ref> <ref>PMID:19801552</ref> <ref>PMID:19293931</ref>
+== References ==
-==About this Structure==
+<references/>
-[[4dg6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DG6 OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
 [[Category: Ceska, T A.]]