4mt2: Difference between revisions

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{{Seed}}
==COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE X-RAY CRYSTAL STRUCTURE OF RAT METALLOTHIONEIN-2==
[[Image:4mt2.png|left|200px]]
<StructureSection load='4mt2' size='340' side='right' caption='[[4mt2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4mt2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. This structure supersedes the now removed PDB entries  and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1mt2 1mt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MT2 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mt2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mt2 RCSB], [http://www.ebi.ac.uk/pdbsum/4mt2 PDBsum]</span></td></tr>
<table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mt/4mt2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Metallothioneins are small cysteine-rich proteins capable of binding heavy metal ions such as Zn2+ and Cd2+. They are ubiquitous tissue components in higher organisms, which tentatively have been attributed both unspecific protective functions against toxic metal ions and highly specific roles in fundamental zinc-regulated cellular processes. In this paper a detailed comparison of the NMR solution structure [Schultze, P., Worgotter, E., Braun, W., Wagner, G., Vasak, M., Kagi, J. H. R. &amp; Wuthrich, K. (1988) J. Mol. Biol. 203, 251-268] and a recent x-ray crystal structure [Robbins, A. H., McRee, D. E., Williamson, M., Collett, S. A., Xoung, N. H., Furey, W. F., Wang, B. C. &amp; Stout, C. D. (1991) J. Mol. Biol. 221, 1269-1293] of rat metallothionein-2 shows that the metallothionein structures in crystals and in solution have identical molecular architectures. The structures obtained with both techniques now present a reliable basis for discussions on structure-function correlations in this class of metalloproteins.


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Comparison of the NMR solution structure and the x-ray crystal structure of rat metallothionein-2.,Braun W, Vasak M, Robbins AH, Stout CD, Wagner G, Kagi JH, Wuthrich K Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10124-8. PMID:1438200<ref>PMID:1438200</ref>
The line below this paragraph, containing "STRUCTURE_4mt2", creates the "Structure Box" on the page.
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{{STRUCTURE_4mt2|  PDB=4mt2  |  SCENE=  }}


===COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE X-RAY CRYSTAL STRUCTURE OF RAT METALLOTHIONEIN-2===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
 
== References ==
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<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_1438200}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1438200 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1438200}}
 
==About this Structure==
4MT2 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MT2 OCA].
 
==Reference==
<ref group="xtra">PMID:1438200</ref><references group="xtra"/>
[[Category: Rattus rattus]]
[[Category: Rattus rattus]]
[[Category: Robbins, A H.]]
[[Category: Robbins, A H.]]
[[Category: Stout, C D.]]
[[Category: Stout, C D.]]
[[Category: Metallothionein]]
[[Category: Metallothionein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:57:41 2009''
Retrieved from "https://proteopedia.org/4mt2"