1bg7: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1bg7.gif|left|200px]] | [[Image:1bg7.gif|left|200px]] | ||
'''LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?''' | {{Structure | ||
|PDB= 1bg7 |SIZE=350|CAPTION= <scene name='initialview01'>1bg7</scene>, resolution 1.85Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?''' | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
1BG7 is a [ | 1BG7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rana_catesbeiana Rana catesbeiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BG7 OCA]. | ||
==Reference== | ==Reference== | ||
Localized unfolding at the junction of three ferritin subunits. A mechanism for iron release?, Takagi H, Shi D, Ha Y, Allewell NM, Theil EC, J Biol Chem. 1998 Jul 24;273(30):18685-8. PMID:[http:// | Localized unfolding at the junction of three ferritin subunits. A mechanism for iron release?, Takagi H, Shi D, Ha Y, Allewell NM, Theil EC, J Biol Chem. 1998 Jul 24;273(30):18685-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9668036 9668036] | ||
[[Category: Rana catesbeiana]] | [[Category: Rana catesbeiana]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 22: | Line 31: | ||
[[Category: iron storage]] | [[Category: iron storage]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:10:33 2008'' | ||
Revision as of 08:10, 20 March 2008
| |||||||||||||
| 1bg7, resolution 1.85Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | CA | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
LOCALIZED UNFOLDING AT THE JUNCTION OF THREE FERRITIN SUBUNITS. A MECHANISM FOR IRON RELEASE?
Overview
How and where iron exits from ferritin for cellular use is unknown. Twenty-four protein subunits create a cavity in ferritin where iron is concentrated >10(11)-fold as a mineral. Proline substitution for conserved leucine 134 (L134P) allowed normal assembly but increased iron exit rates. X-ray crystallography of H-L134P ferritin revealed localized unfolding at the 3-fold axis, also iron entry sites, consistent with shared use sites for iron exit and entry. The junction of three ferritin subunits appears to be a dynamic aperture with a "shutter" that cytoplasmic factors might open or close to regulate iron release in vivo.
About this Structure
1BG7 is a Single protein structure of sequence from Rana catesbeiana. Full crystallographic information is available from OCA.
Reference
Localized unfolding at the junction of three ferritin subunits. A mechanism for iron release?, Takagi H, Shi D, Ha Y, Allewell NM, Theil EC, J Biol Chem. 1998 Jul 24;273(30):18685-8. PMID:9668036
Page seeded by OCA on Thu Mar 20 10:10:33 2008
