1koc: Difference between revisions

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[[~~Image~~:~~1koc~~.~~png~~|~~left~~|~~200px~~]]

==RNA APTAMER COMPLEXED WITH ARGININE, NMR==

== Structural highlights ==

<table><tr><td colspan='2'>[[1koc]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KOC FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene><br>

<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kod|1kod]]</td></tr>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1koc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1koc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1koc RCSB], [http://www.ebi.ac.uk/pdbsum/1koc PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

In a previous study, an RNA aptamer for the specific recognition of arginine was evolved from a parent sequence that bound citrulline specifically. The two RNAs differ at only 3 positions out of 44. The solution structures of the two aptamers complexed to their cognate amino acids have now been determined by two-dimensional nuclear magnetic resonance spectroscopy. Both aptamers contain two asymmetrical internal loops that are not well ordered in the free RNA but that fold into a compact structure upon ligand binding. Those nucleotides common to both RNAs include a conserved cluster of purine residues, three of which form an uneven plane containing a G:G pair, and two other residues nearly perpendicular to that surface. Two of the three variant nucleotides are stacked on the cluster of purines and form a triple contact to the amino acid side chain, whereas the edge of the third variant nucleotide is capping the binding pocket.

~~{{STRUCTURE_1koc| PDB=1koc | SCENE= }}~~

Structural basis of ligand discrimination by two related RNA aptamers resolved by NMR spectroscopy.,Yang Y, Kochoyan M, Burgstaller P, Westhof E, Famulok M Science. 1996 May 31;272(5266):1343-7. PMID:8650546<ref>PMID:8650546</ref>

~~===RNA APTAMER COMPLEXED WITH ARGININE~~, ~~NMR===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_8650546}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[1koc]] is~~ a ~~2 chain structure. Full experimental information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1KOC OCA].~~

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:008650546<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Burgstaller, P.]]

[[Category: Famulok, M.]]

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@@ Line 1: / Line 1: @@
-[[Image:1koc.png|left|200px]]
+==RNA APTAMER COMPLEXED WITH ARGININE, NMR==
+<StructureSection load='1koc' size='340' side='right' caption='[[1koc]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1koc]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KOC FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene><br>
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kod|1kod]]</td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1koc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1koc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1koc RCSB], [http://www.ebi.ac.uk/pdbsum/1koc PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+In a previous study, an RNA aptamer for the specific recognition of arginine was evolved from a parent sequence that bound citrulline specifically. The two RNAs differ at only 3 positions out of 44. The solution structures of the two aptamers complexed to their cognate amino acids have now been determined by two-dimensional nuclear magnetic resonance spectroscopy. Both aptamers contain two asymmetrical internal loops that are not well ordered in the free RNA but that fold into a compact structure upon ligand binding. Those nucleotides common to both RNAs include a conserved cluster of purine residues, three of which form an uneven plane containing a G:G pair, and two other residues nearly perpendicular to that surface. Two of the three variant nucleotides are stacked on the cluster of purines and form a triple contact to the amino acid side chain, whereas the edge of the third variant nucleotide is capping the binding pocket.
-{{STRUCTURE_1koc|  PDB=1koc  |  SCENE=  }}
+Structural basis of ligand discrimination by two related RNA aptamers resolved by NMR spectroscopy.,Yang Y, Kochoyan M, Burgstaller P, Westhof E, Famulok M Science. 1996 May 31;272(5266):1343-7. PMID:8650546<ref>PMID:8650546</ref>
-===RNA APTAMER COMPLEXED WITH ARGININE, NMR===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_8650546}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[1koc]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOC OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:008650546</ref><references group="xtra"/>
 [[Category: Burgstaller, P.]]
 [[Category: Famulok, M.]]