1bau: Difference between revisions

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[[~~Image~~:1bau.~~png|left|200px~~]]

==NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE==

== Structural highlights ==

<table><tr><td colspan='2'>[[1bau]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BAU FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bau OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bau RCSB], [http://www.ebi.ac.uk/pdbsum/1bau PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

Retroviral genomes must dimerize to be fully infectious. Dimerization is directed by a unique RNA hairpin structure with a palindrome in its loop: hairpins of two strands first associate transiently through their loops, and then refold to a more stable, linear duplex. The structure of the initial, kissing-loop dimer from HIV-1, solved using 2D NMR, is bent and metastable, its interface being formed not only by standard basepairing between palindromes, but also by a distinctive pattern of interstrand stacking among bases at the stem-loop junctions. This creates mechanical distortions that partially melt both stems, which may facilitate spontaneous refolding of this RNA complex into linear form.

~~{{STRUCTURE_1bau| PDB=1bau | SCENE= }}~~

Structure of the dimer initiation complex of HIV-1 genomic RNA.,Mujeeb A, Clever JL, Billeci TM, James TL, Parslow TG Nat Struct Biol. 1998 Jun;5(6):432-6. PMID:9628479<ref>PMID:9628479</ref>

~~===NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA~~, ~~MINIMIZED AVERAGE STRUCTURE===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_9628479}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[1bau]] is~~ a ~~2 chain structure. Full experimental information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=1BAU OCA].~~

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:009628479<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Billeci, T M.]]

[[Category: Clever, J L.]]

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@@ Line 1: / Line 1: @@
-[[Image:1bau.png|left|200px]]
+==NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE==
+<StructureSection load='1bau' size='340' side='right' caption='[[1bau]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1bau]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BAU FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bau OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bau RCSB], [http://www.ebi.ac.uk/pdbsum/1bau PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Retroviral genomes must dimerize to be fully infectious. Dimerization is directed by a unique RNA hairpin structure with a palindrome in its loop: hairpins of two strands first associate transiently through their loops, and then refold to a more stable, linear duplex. The structure of the initial, kissing-loop dimer from HIV-1, solved using 2D NMR, is bent and metastable, its interface being formed not only by standard basepairing between palindromes, but also by a distinctive pattern of interstrand stacking among bases at the stem-loop junctions. This creates mechanical distortions that partially melt both stems, which may facilitate spontaneous refolding of this RNA complex into linear form.
-{{STRUCTURE_1bau|  PDB=1bau  |  SCENE=  }}
+Structure of the dimer initiation complex of HIV-1 genomic RNA.,Mujeeb A, Clever JL, Billeci TM, James TL, Parslow TG Nat Struct Biol. 1998 Jun;5(6):432-6. PMID:9628479<ref>PMID:9628479</ref>
-===NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_9628479}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[1bau]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAU OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:009628479</ref><references group="xtra"/>
 [[Category: Billeci, T M.]]
 [[Category: Clever, J L.]]