2gku: Difference between revisions

Line 1:

[[~~Image~~:~~2gku~~.~~png~~|~~left~~|~~200px~~]]

==Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures==

== Structural highlights ==

<table><tr><td colspan='2'>[[2gku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GKU FirstGlance]. <br>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gku RCSB], [http://www.ebi.ac.uk/pdbsum/2gku PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.

~~{{STRUCTURE_2gku| PDB=2gku | SCENE= }}~~

Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold.,Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:16866556<ref>PMID:16866556</ref>

~~===Monomeric human telomere DNA tetraplex with 3+1 strand fold topology~~, ~~two edgewise loops and double-chain reversal loop, NMR, 12 structures===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_16866556}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[2gku]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2GKU OCA].~~

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:016866556<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Homo sapiens]]

[[Category: Kuryavyi, V V.]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:2gku.png|left|200px]]
+==Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures==
+<StructureSection load='2gku' size='340' side='right' caption='[[2gku]], [[NMR_Ensembles_of_Models | 12 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2gku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GKU FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[143d|143d]], [[186d|186d]], [[1k8p|1k8p]], [[2aqy|2aqy]]</td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gku OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gku RCSB], [http://www.ebi.ac.uk/pdbsum/2gku PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K(+) solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na(+) solution and in a K(+)-containing crystal, involves the following: one anti.syn.syn.syn and two syn.anti.anti.anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.
-{{STRUCTURE_2gku|  PDB=2gku  |  SCENE=  }}
+Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold.,Luu KN, Phan AT, Kuryavyi V, Lacroix L, Patel DJ J Am Chem Soc. 2006 Aug 2;128(30):9963-70. PMID:16866556<ref>PMID:16866556</ref>
-===Monomeric human telomere DNA tetraplex with 3+1 strand fold topology, two edgewise loops and double-chain reversal loop, NMR, 12 structures===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_16866556}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[2gku]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GKU OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:016866556</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
 [[Category: Kuryavyi, V V.]]