1bjf: Difference between revisions
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[[Image:1bjf.jpg|left|200px]] | [[Image:1bjf.jpg|left|200px]] | ||
'''CRYSTAL STRUCTURE OF RECOMBINANT BOVINE NEUROCALCIN DELTA AT 2.4 ANGSTROMS''' | {{Structure | ||
|PDB= 1bjf |SIZE=350|CAPTION= <scene name='initialview01'>1bjf</scene>, resolution 2.4Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''CRYSTAL STRUCTURE OF RECOMBINANT BOVINE NEUROCALCIN DELTA AT 2.4 ANGSTROMS''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1BJF is a [ | 1BJF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJF OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of recombinant bovine neurocalcin., Vijay-Kumar S, Kumar VD, Nat Struct Biol. 1999 Jan;6(1):80-8. PMID:[http:// | Crystal structure of recombinant bovine neurocalcin., Vijay-Kumar S, Kumar VD, Nat Struct Biol. 1999 Jan;6(1):80-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9886296 9886296] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: neuronal specific guanylate cyclase activator]] | [[Category: neuronal specific guanylate cyclase activator]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:11:50 2008'' | ||
Revision as of 08:11, 20 March 2008
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| 1bjf, resolution 2.4Å | |||||||||||||
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| Ligands: | CA | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
CRYSTAL STRUCTURE OF RECOMBINANT BOVINE NEUROCALCIN DELTA AT 2.4 ANGSTROMS
Overview
The crystal structure of calcium-bound unmyristoylated bovine neurocalcin from Escherichia coli has been determined at 2.4 A resolution. The three-dimensional structure reveals a highly compact structure consisting of: (i) two pairs of calcium-binding EF-hands (EF1-EF2 and EF3-EF4); (ii) a calcium ion bound at EF2, EF3 and EF4 sites; and (iii) an EF1-hand that is disabled from calcium-binding due to a Cys-Pro sequence in the Ca2+-binding loop. The crystal structure of neurocalcin resembles photoreceptor recoverin in overall topology, however its EF2- and EF4-hands differ. Recently, neurocalcin in the calcium-bound state has been shown to stimulate mammalian rod outer segment membrane guanylate cyclase. A possible site for cyclase activity based on the three-dimensional structure is discussed.
About this Structure
1BJF is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Crystal structure of recombinant bovine neurocalcin., Vijay-Kumar S, Kumar VD, Nat Struct Biol. 1999 Jan;6(1):80-8. PMID:9886296
Page seeded by OCA on Thu Mar 20 10:11:50 2008
