1zc5: Difference between revisions

Line 1:

[[~~Image~~:1zc5.~~png|left|200px~~]]

==Structure of the RNA signal essential for translational frameshifting in HIV-1==

== Structural highlights ==

<table><tr><td colspan='2'>[[1zc5]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZC5 FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zc5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zc5 RCSB], [http://www.ebi.ac.uk/pdbsum/1zc5 PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

Many pathogenic viruses use a programmed -1 translational frameshifting mechanism to regulate synthesis of their structural and enzymatic proteins. Frameshifting is vital for viral replication. A slippery sequence bound at the ribosomal A and P sites as well as a downstream stimulatory RNA structure are essential for frameshifting. Conflicting data have been reported concerning the structure of the downstream RNA signal in human immunodeficiency virus type 1 (HIV-1). Here, the solution structure of the HIV-1 frameshifting RNA signal was solved by heteronuclear NMR spectroscopy. This structure reveals a long hairpin fold with an internal three-nucleotide bulge. The internal loop introduces a bend between the lower and upper helical regions, a structural feature often seen in frameshifting pseudoknots. The NMR structure correlates with chemical probing data. The upper stem rich in conserved G-C Watson-Crick base-pairs is highly stable, whereas the bulge region and the lower stem are more flexible.

~~{{STRUCTURE_1zc5| PDB=1zc5 | SCENE= }}~~

Structure of the RNA signal essential for translational frameshifting in HIV-1.,Gaudin C, Mazauric MH, Traikia M, Guittet E, Yoshizawa S, Fourmy D J Mol Biol. 2005 Jun 24;349(5):1024-35. PMID:15907937<ref>PMID:15907937</ref>

~~===Structure~~ of the ~~RNA signal essential for translational frameshifting in HIV-1===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_15907937}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[1zc5]] is a 1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=1ZC5 OCA].~~

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:015907937<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Fourmy, D.]]

[[Category: Gaudin, C.]]

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@@ Line 1: / Line 1: @@
-[[Image:1zc5.png|left|200px]]
+==Structure of the RNA signal essential for translational frameshifting in HIV-1==
+<StructureSection load='1zc5' size='340' side='right' caption='[[1zc5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1zc5]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZC5 FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zc5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zc5 RCSB], [http://www.ebi.ac.uk/pdbsum/1zc5 PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Many pathogenic viruses use a programmed -1 translational frameshifting mechanism to regulate synthesis of their structural and enzymatic proteins. Frameshifting is vital for viral replication. A slippery sequence bound at the ribosomal A and P sites as well as a downstream stimulatory RNA structure are essential for frameshifting. Conflicting data have been reported concerning the structure of the downstream RNA signal in human immunodeficiency virus type 1 (HIV-1). Here, the solution structure of the HIV-1 frameshifting RNA signal was solved by heteronuclear NMR spectroscopy. This structure reveals a long hairpin fold with an internal three-nucleotide bulge. The internal loop introduces a bend between the lower and upper helical regions, a structural feature often seen in frameshifting pseudoknots. The NMR structure correlates with chemical probing data. The upper stem rich in conserved G-C Watson-Crick base-pairs is highly stable, whereas the bulge region and the lower stem are more flexible.
-{{STRUCTURE_1zc5|  PDB=1zc5  |  SCENE=  }}
+Structure of the RNA signal essential for translational frameshifting in HIV-1.,Gaudin C, Mazauric MH, Traikia M, Guittet E, Yoshizawa S, Fourmy D J Mol Biol. 2005 Jun 24;349(5):1024-35. PMID:15907937<ref>PMID:15907937</ref>
-===Structure of the RNA signal essential for translational frameshifting in HIV-1===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_15907937}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[1zc5]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZC5 OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:015907937</ref><references group="xtra"/>
 [[Category: Fourmy, D.]]
 [[Category: Gaudin, C.]]