2dz7: Difference between revisions

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[[~~Image~~:2dz7.~~png|left|200px~~]]

==DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)==

== Structural highlights ==

<table><tr><td colspan='2'>[[2dz7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DZ7 FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dz7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dz7 RCSB], [http://www.ebi.ac.uk/pdbsum/2dz7 PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

The crystal structure of the tetragonal form of d(gcGAAAgc) has been revised and reasonably refined including the disordered residues. The two DNA strands form a base-intercalated duplex, and the four duplexes are assembled according to the crystallographic 222 symmetry to form an octaplex. In the central region, the eight strands are associated by I-motif of double A-quartets. Furthermore, eight hydrated-magnesium cations link the four duplexes to support the octaplex formation. Based on these structural features, a proposal that folding of d(GAAA)n, found in the non-coding region of genomes, into an octaplex can induce slippage during replication to facilitate length polymorphism is presented.

~~{{STRUCTURE_2dz7| PDB=2dz7 | SCENE= }}~~

DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC).,Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A J Biochem. 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:17062599<ref>PMID:17062599</ref>

~~===DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure~~ of ~~d(GCGAAAGC)===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_17062599}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[2dz7]] is a 1 chain structure. Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2DZ7 OCA].~~

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:017062599<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Kondo, J.]]

[[Category: Mitomi, K.]]

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@@ Line 1: / Line 1: @@
-[[Image:2dz7.png|left|200px]]
+==DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)==
+<StructureSection load='2dz7' size='340' side='right' caption='[[2dz7]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2dz7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DZ7 FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dz7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dz7 RCSB], [http://www.ebi.ac.uk/pdbsum/2dz7 PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The crystal structure of the tetragonal form of d(gcGAAAgc) has been revised and reasonably refined including the disordered residues. The two DNA strands form a base-intercalated duplex, and the four duplexes are assembled according to the crystallographic 222 symmetry to form an octaplex. In the central region, the eight strands are associated by I-motif of double A-quartets. Furthermore, eight hydrated-magnesium cations link the four duplexes to support the octaplex formation. Based on these structural features, a proposal that folding of d(GAAA)n, found in the non-coding region of genomes, into an octaplex can induce slippage during replication to facilitate length polymorphism is presented.
-{{STRUCTURE_2dz7|  PDB=2dz7  |  SCENE=  }}
+DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC).,Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A J Biochem. 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:17062599<ref>PMID:17062599</ref>
-===DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_17062599}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[2dz7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZ7 OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:017062599</ref><references group="xtra"/>
 [[Category: Kondo, J.]]
 [[Category: Mitomi, K.]]