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[[Image:3slu.png|left|200px]]
==Crystal structure of NMB0315==
<StructureSection load='3slu' size='340' side='right' caption='[[3slu]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3slu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SLU FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HMPREF0602_0018 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 Neisseria meningitidis])</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3slu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3slu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3slu RCSB], [http://www.ebi.ac.uk/pdbsum/3slu PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
NMB0315 is an outer membrane protein of Neisseria meningitidis serogroup B (NMB) and a potential candidate for a broad-spectrum vaccine against meningococcal disease. The crystal structure of NMB0315 was solved by single-wavelength anomalous dispersion (SAD) at a resolution of 2.4 A and revealed to be a lysostaphin-type peptidase of the M23 metallopeptidase family. The overall structure consists of three well-separated domains and has no similarity to any previously published structure. However, only the topology of the carboxyl-terminal domain is highly conserved among members of this family, and this domain is a zinc-dependent catalytic unit. The amino-terminal domain of the structure blocks the substrate binding pocket in the carboxyl-terminal domain, indicating that the wild-type full-length protein is in an inactive conformational state. Our studies improve the understanding of the catalytic mechanism of M23 metallopeptidases.


{{STRUCTURE_3slu|  PDB=3slu  |  SCENE=  }}
Crystal structure of outer membrane protein NMB0315 from Neisseria meningitidis.,Wang X, Yang X, Yang C, Wu Z, Xu H, Shen Y PLoS One. 2011;6(10):e26845. Epub 2011 Oct 26. PMID:22046377<ref>PMID:22046377</ref>


===Crystal structure of NMB0315===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_22046377}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[3slu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SLU OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:022046377</ref><references group="xtra"/>
[[Category: Neisseria meningitidis]]
[[Category: Neisseria meningitidis]]
[[Category: Shen, Y.]]
[[Category: Shen, Y.]]
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