1ue3: Difference between revisions

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[[Image:1ue3.png|left|200px]]
==Crystal structure of d(GCGAAAGC) containing hexaamminecobalt==
<StructureSection load='1ue3' size='340' side='right' caption='[[1ue3]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ue3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UE3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UE3 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene><br>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ue2|1ue2]], [[1ue4|1ue4]]</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ue3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ue3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ue3 RCSB], [http://www.ebi.ac.uk/pdbsum/1ue3 PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A DNA fragment d(GCGAAAGC), postulated to adopt a stable mini-hairpin structure on the basis of its extraordinary properties, has been X-ray analyzed. Two octamers related by a crystallographic twofold symmetry are aligned in an antiparallel fashion and associate to form a duplex, which is maintained by two Watson-Crick G.C base pairs and a subsequent sheared G.A pair at both ends. The central two A residues are free from base-pair formation. The corresponding base moieties of the two strands are intercalated and stacked on each other, forming a long column of G(1)-C(2)-G(3)-A(4)-A(5)(*)-A(5)-A(4)(*)-G(3)(*)-C(2)(*)-G(1)(*) (asterisks indicate the counter-strand). The Watson-Crick and major-groove sites of the four stacked adenine bases are exposed to the solvent region, suggesting a functional role. Since this structural motif is similar to those found in the nonamers d(G(Br)CGAAAGCT) and d(G(I)CGAAAGCT), the base-intercalated duplex may be a stable form of the specific sequence. Electrophoresis results suggest that the octamer has two states, monomeric and dimeric, in solution depending on the Mg(2+) concentration. The present duplex is preferred under the crystallization conditions, which correspond to physiologically allowed conditions.


{{STRUCTURE_1ue3|  PDB=1ue3  |  SCENE=  }}
Structure of d(GCGAAAGC) (hexagonal form): a base-intercalated duplex as a stable structure.,Sunami T, Kondo J, Hirao I, Watanabe K, Miura KI, Takenaka A Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):90-6. Epub 2003 Dec, 18. PMID:14684897<ref>PMID:14684897</ref>


===Crystal structure of d(GCGAAAGC) containing hexaamminecobalt===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_14684897}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[1ue3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UE3 OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:014684897</ref><references group="xtra"/>
[[Category: Hirao, I.]]
[[Category: Hirao, I.]]
[[Category: Kondo, J.]]
[[Category: Kondo, J.]]
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