1qh2: Difference between revisions

Line 1:

[[~~Image~~:1qh2.~~png|left|200px~~]]

==CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA==

== Structural highlights ==

<table><tr><td colspan='2'>[[1qh2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QH2 FirstGlance]. <br>

</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qh2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qh2 RCSB], [http://www.ebi.ac.uk/pdbsum/1qh2 PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

Female reproductive tissues of the ornamental tobacco amass high levels of serine proteinase inhibitors (PIs) for protection against pests and pathogens. These PIs are produced from a precursor protein composed of six repeats each with a protease reactive site. Here we show that proteolytic processing of the precursor generates five single-chain PIs and a remarkable two-chain inhibitor formed by disulfide-bond linkage of N- and C-terminal peptide fragments. Surprisingly, PI precursors adopt this circular structure regardless of the number of inhibitor domains, suggesting this bracelet-like conformation is characteristic of the widespread potato inhibitor II (Pot II) protein family.

~~{{STRUCTURE_1qh2| PDB=1qh2 | SCENE= }}~~

A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein.,Lee MC, Scanlon MJ, Craik DJ, Anderson MA Nat Struct Biol. 1999 Jun;6(6):526-30. PMID:10360353<ref>PMID:10360353</ref>

~~===CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_10360353}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[1qh2]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Nicotiana_alata Nicotiana alata]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA].~~

</StructureSection>

==~~Reference~~==

<~~ref group="xtra">PMID:010360353<~~/~~ref><ref group="xtra">PMID:010731432</ref~~><~~references group="xtra"~~/>

[[Category: Nicotiana alata]]

[[Category: Anderson, M A.]]

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@@ Line 1: / Line 1: @@
-[[Image:1qh2.png|left|200px]]
+==CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA==
+<StructureSection load='1qh2' size='340' side='right' caption='[[1qh2]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1qh2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QH2 FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qh2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qh2 RCSB], [http://www.ebi.ac.uk/pdbsum/1qh2 PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Female reproductive tissues of the ornamental tobacco amass high levels of serine proteinase inhibitors (PIs) for protection against pests and pathogens. These PIs are produced from a precursor protein composed of six repeats each with a protease reactive site. Here we show that proteolytic processing of the precursor generates five single-chain PIs and a remarkable two-chain inhibitor formed by disulfide-bond linkage of N- and C-terminal peptide fragments. Surprisingly, PI precursors adopt this circular structure regardless of the number of inhibitor domains, suggesting this bracelet-like conformation is characteristic of the widespread potato inhibitor II (Pot II) protein family.
-{{STRUCTURE_1qh2|  PDB=1qh2  |  SCENE=  }}
+A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein.,Lee MC, Scanlon MJ, Craik DJ, Anderson MA Nat Struct Biol. 1999 Jun;6(6):526-30. PMID:10360353<ref>PMID:10360353</ref>
-===CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_10360353}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[1qh2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:010360353</ref><ref group="xtra">PMID:010731432</ref><references group="xtra"/>
 [[Category: Nicotiana alata]]
 [[Category: Anderson, M A.]]