1s9s: Difference between revisions
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[[ | ==SOLUTION STRUCTURE OF MLV PSI SITE== | ||
<StructureSection load='1s9s' size='340' side='right' caption='[[1s9s]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1s9s]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S9S FirstGlance]. <br> | |||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s9s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s9s RCSB], [http://www.ebi.ac.uk/pdbsum/1s9s PDBsum]</span></td></tr> | |||
<table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The full length, positive-strand genome of the Moloney Murine Leukemia Virus contains a "core encapsidation signal" that is essential for efficient genome packaging during virus assembly. We have determined the structure of a 101-nucleotide RNA that contains this signal (called mPsi) using a novel isotope-edited NMR approach. The method is robust and should be generally applicable to larger RNAs. mPsi folds into three stem loops, two of which (SL-C and SL-D) co-stack to form an extended helix. The third stem loop (SL-B) is connected to SL-C by a flexible, four-nucleotide linker. The structure contains five mismatched base-pairs, an unusual C.CG base-triple platform, and a novel "A-minor K-turn," in which unpaired adenosine bases A340 and A341 of a GGAA bulge pack in the minor groove of a proximal stem, and a bulged distal uridine (U319) forms a hydrogen bond with the phosphodiester of A341. Phylogenetic analyses indicate that these essential structural elements are conserved among the murine C-type retroviruses. | |||
NMR structure of the 101-nucleotide core encapsidation signal of the Moloney murine leukemia virus.,D'Souza V, Dey A, Habib D, Summers MF J Mol Biol. 2004 Mar 19;337(2):427-42. PMID:15003457<ref>PMID:15003457</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
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[[Category: Dey, A.]] | [[Category: Dey, A.]] | ||
[[Category: Habib, D.]] | [[Category: Habib, D.]] | ||
Revision as of 07:11, 9 June 2014
SOLUTION STRUCTURE OF MLV PSI SITE
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